DPM1 and TDO2

Data Source:
BioGRID (two hybrid)

		DPM1	TDO2
Description		dolichyl-phosphate mannosyltransferase subunit 1, catalytic	tryptophan 2,3-dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex	Cytosol
	Molecular Function	Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding	Tryptophan 2,3-dioxygenase Activity Protein Binding Amino Acid Binding Oxygen Binding Heme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Protein Mannosylation Protein O-linked Mannosylation	Tryptophan Catabolic Process Tryptophan Catabolic Process To Kynurenine Tryptophan Catabolic Process To Acetyl-CoA Protein Homotetramerization Response To Nitroglycerin
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)	Tryptophan catabolism
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)	Blood metabolite levels ( 24816252) Manganese levels ( 26025379) Speech perception in dyslexia ( 19786962)
Interacting Genes		7 interacting genes: DPM2 DPM3 MEOX2 MTNR1A PTEN TDO2 ZBTB16	20 interacting genes: ASMTL DPM1 EIF4E KDM1A LMNA LNX1 MEOX2 MOB1A MOB3C NGB NMNAT1 NR1D1 PICK1 PM20D2 PRMT6 PSMA1 REL SDCBP SDCBP2 ZFYVE26
Entrez ID		8813	6999
HPRD ID		04613	01847
Ensembl ID		ENSG00000000419	ENSG00000151790
Uniprot IDs		A0A0S2Z4Y5 O60762 Q5QPK2	P48775
PDB IDs			4PW8 5TI9 5TIA 6A4I 6PYY 6PYZ 6VBN
Enriched GO Terms of Interacting Partners?
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