MPDZ and CLDN1

Data Source:
HPRD (two hybrid, in vitro)

		MPDZ	CLDN1
Description		multiple PDZ domain crumbs cell polarity complex component	claudin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Bicellular Tight Junction Postsynaptic Density Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Tight Junction
	Molecular Function	Protein Binding Protein C-terminus Binding	Virus Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Viral Process	Cell Adhesion Aging Establishment Of Blood-nerve Barrier Response To Toxic Substance Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Positive Regulation Of Cell Migration Response To Lipopolysaccharide Cell Junction Maintenance Maintenance Of Blood-brain Barrier Hyperosmotic Salinity Response Cell-cell Junction Organization Response To Ethanol Viral Entry Into Host Cell Protein Complex Oligomerization Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Establishment Of Skin Barrier Xenobiotic Transport Across Blood-nerve Barrier Response To Interleukin-18 Bicellular Tight Junction Assembly Cellular Response To Lead Ion Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Response To Dexamethasone Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Wound Healing Establishment Of Endothelial Intestinal Barrier Liver Regeneration Positive Regulation Of Bicellular Tight Junction Assembly Cellular Response To Butyrate
Pathways			Tight junction interactions
Drugs
Diseases			Neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome; Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC)
GWAS		Central corneal thickness ( 32528159 29760442) Corneal hysteresis ( 30894546) Corneal structure ( 23291589) Heel bone mineral density ( 30598549 28869591) Refractive astigmatism ( 30306274) Triglyceride levels ( 32203549)	Optic disc size ( 31809533) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		16 interacting genes: ABCA1 CAMK2A CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2	18 interacting genes: BRD4 CD69 CD79A CLDN3 DRG1 FNDC9 LNX1 MMP14 MMP2 MPDZ MS4A3 PATJ TJP1 TJP2 TJP3 TMEM179B TMEM9 WNK4
Entrez ID		8777	9076
HPRD ID		09155	04760
Ensembl ID		ENSG00000107186	ENSG00000163347
Uniprot IDs		O75970	A5JSJ9 O95832
PDB IDs		2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?
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