GBF1 and USO1

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vitro, in vivo, two hybrid)

		GBF1	USO1
Description		golgi brefeldin A resistant guanine nucleotide exchange factor 1	USO1 vesicle transport factor
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Trans-Golgi Network Lipid Droplet Cytosol Membrane Cell Leading Edge	Golgi Membrane Fibrillar Center Endoplasmic Reticulum Golgi Apparatus Golgi Stack Cytosol ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	RNA Binding Protein Binding Cadherin Binding
	Biological Process	Cell Activation Involved In Immune Response Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Golgi Organization Regulation Of Mitotic Cell Cycle Protein Transport Viral Process Neutrophil Chemotaxis Regulation Of ARF Protein Signal Transduction Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi COPI Coating Of Golgi Vesicle Regulation Of Catalytic Activity Establishment Of Monopolar Cell Polarity Protein Localization To Endoplasmic Reticulum Exit Site Golgi Disassembly Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Cellular Response To Virus Reactive Oxygen Species Biosynthetic Process Protein Localization To Endoplasmic Reticulum Tubular Network Regulation Of Protein Localization To Cell Surface	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Small GTPase Mediated Signal Transduction Secretory Granule Localization Transcytosis COPII Vesicle Coating Golgi Vesicle Docking Vesicle Fusion With Golgi Apparatus Membrane Fusion Regulation Of Cellular Response To Insulin Stimulus
Pathways		trans-Golgi Network Vesicle Budding VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport
Drugs
Diseases
GWAS		Adult body size ( 32376654) General cognitive ability ( 29844566) Hand grip strength ( 29313844) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) QT interval ( 24952745) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Triglyceride levels ( 32154731) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763)
Interacting Genes		7 interacting genes: CDK1 PNPLA2 SRPK2 UBC USO1 YWHAG ZYG11B	25 interacting genes: AKAP9 BET1L C1orf94 CASP3 CASP8 CSNK2B DUSP12 EEA1 GABPB1 GAK GBF1 GOLGA2 GOLGB1 GOSR1 GOSR2 NSF PHYKPL PLCG1 RAB1A RPL9 SCFD1 STX5 STXBP1 XPO7 YKT6
Entrez ID		8729	8615
HPRD ID		04740	09135
Ensembl ID		ENSG00000107862	ENSG00000138768
Uniprot IDs		A0A669KBG8 Q92538	O60763
PDB IDs			2W3C
Enriched GO Terms of Interacting Partners?
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