USO1 and GAK

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		USO1	GAK
Description		USO1 vesicle transport factor	cyclin G associated kinase
Image
GO Annotations	Cellular Component	Golgi Membrane Fibrillar Center Endoplasmic Reticulum Golgi Apparatus Golgi Stack Cytosol ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Perinuclear Region Of Cytoplasm	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	RNA Binding Protein Binding Cadherin Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Clathrin Binding Cyclin Binding Chaperone Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Small GTPase Mediated Signal Transduction Secretory Granule Localization Transcytosis COPII Vesicle Coating Golgi Vesicle Docking Vesicle Fusion With Golgi Apparatus Membrane Fusion Regulation Of Cellular Response To Insulin Stimulus	Protein Phosphorylation Receptor-mediated Endocytosis Endoplasmic Reticulum Organization Golgi Organization Cell Cycle Negative Regulation Of Neuron Projection Development Synaptic Vesicle Uncoating Protein Localization To Golgi Apparatus Chaperone Cofactor-dependent Protein Refolding Membrane Organization Clathrin Coat Disassembly Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane Golgi To Lysosome Transport Clathrin-coated Pit Assembly
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs			Fostamatinib
Diseases
GWAS		Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763)	HDL cholesterol ( 30275531) Mortality in sepsis ( 27639821) Parkinson's disease ( 20711177 21292315 25064009 27182965 22438815 21738487 32310270) Parkinson's disease (age of onset) ( 30957308) Parkinson's disease (familial) ( 18985386) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cholangitis ( 26394269) Triglycerides ( 30275531)
Interacting Genes		25 interacting genes: AKAP9 BET1L C1orf94 CASP3 CASP8 CSNK2B DUSP12 EEA1 GABPB1 GAK GBF1 GOLGA2 GOLGB1 GOSR1 GOSR2 NSF PHYKPL PLCG1 RAB1A RPL9 SCFD1 STX5 STXBP1 XPO7 YKT6	14 interacting genes: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 LRRK1 MFHAS1 USO1
Entrez ID		8615	2580
HPRD ID		09135	03631
Ensembl ID		ENSG00000138768	ENSG00000178950
Uniprot IDs		O60763	B4DS37 O14976
PDB IDs		2W3C	4C57 4C58 4C59 4O38 4Y8D 5Y7Z 5Y80
Enriched GO Terms of Interacting Partners?
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