GBF1 and PNPLA2

Data Source:
BioGRID (pull down, pull down, imaging technique)

		GBF1	PNPLA2
Description		golgi brefeldin A resistant guanine nucleotide exchange factor 1	patatin like phospholipase domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Trans-Golgi Network Lipid Droplet Cytosol Membrane Cell Leading Edge	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Triglyceride Lipase Activity Retinyl-palmitate Esterase Activity
	Biological Process	Cell Activation Involved In Immune Response Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Golgi Organization Regulation Of Mitotic Cell Cycle Protein Transport Viral Process Neutrophil Chemotaxis Regulation Of ARF Protein Signal Transduction Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi COPI Coating Of Golgi Vesicle Regulation Of Catalytic Activity Establishment Of Monopolar Cell Polarity Protein Localization To Endoplasmic Reticulum Exit Site Golgi Disassembly Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Cellular Response To Virus Reactive Oxygen Species Biosynthetic Process Protein Localization To Endoplasmic Reticulum Tubular Network Regulation Of Protein Localization To Cell Surface	Diacylglycerol Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Lipid Homeostasis
Pathways		trans-Golgi Network Vesicle Budding VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Adult body size ( 32376654) General cognitive ability ( 29844566) Hand grip strength ( 29313844) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) QT interval ( 24952745) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Triglyceride levels ( 32154731) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body fat distribution (arm fat ratio) ( 30664634) HDL cholesterol levels ( 32203549) Keratoconus ( 31855235)
Interacting Genes		7 interacting genes: CDK1 PNPLA2 SRPK2 UBC USO1 YWHAG ZYG11B	10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2
Entrez ID		8729	57104
HPRD ID		04740	11443
Ensembl ID		ENSG00000107862	ENSG00000177666
Uniprot IDs		A0A669KBG8 Q92538	Q96AD5
PDB IDs
Enriched GO Terms of Interacting Partners?
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