SNX3 and USP10

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SNX3	USP10
Description		sorting nexin 3	ubiquitin specific peptidase 10
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Endosome Membrane Clathrin-coated Vesicle Retromer Complex Early Endosome Membrane Early Phagosome Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Protein-containing Complex Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Ion Channel Binding
	Biological Process	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Protein Transport Wnt Signaling Pathway Protein Deubiquitination Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Endocytic Recycling Late Endosome To Golgi Transport Negative Regulation Of Protein Catabolic Process Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport	Ubiquitin-dependent Protein Catabolic Process Autophagy Cellular Response To DNA Damage Stimulus Regulation Of Autophagy Protein Deubiquitination Protein Phosphopantetheinylation Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1
Pathways		WNT ligand biogenesis and trafficking Ub-specific processing proteases	Termination of translesion DNA synthesis Ub-specific processing proteases
Drugs		S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS			Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		12 interacting genes: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 RAB7A RPRM SCNN1A STX11 TSC22D2 USP10 VPS35	16 interacting genes: AR G3BP1 G3BP2 H2AC20 IKBKG MSH2 NOTCH1 PRKAA2 RACK1 RAD51 SCNN1A SCNN1G SIRT6 SMAD4 SNX3 UBC
Entrez ID		8724	9100
HPRD ID		09333	07029
Ensembl ID		ENSG00000112335	ENSG00000103194
Uniprot IDs		O60493	Q14694
PDB IDs		2MXC 2YPS 5F0J 5F0L 5F0M 5F0P
Enriched GO Terms of Interacting Partners?
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