SNX3 and VPS35

Data Source:
BioGRID (pull down)

		SNX3	VPS35
Description		sorting nexin 3	VPS35 retromer complex component
Image
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Endosome Membrane Clathrin-coated Vesicle Retromer Complex Early Endosome Membrane Early Phagosome Extracellular Exosome	Mitochondrion Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Retromer Complex Retromer, Cargo-selective Complex Extracellular Exosome Tubular Endosome Mitochondrion-derived Vesicle
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding D1 Dopamine Receptor Binding
	Biological Process	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Protein Transport Wnt Signaling Pathway Protein Deubiquitination Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Endocytic Recycling Late Endosome To Golgi Transport Negative Regulation Of Protein Catabolic Process Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport	Intracellular Protein Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Viral Process Wnt Signaling Pathway Regulation Of Macroautophagy Regulation Of Protein Stability Regulation Of Cellular Protein Metabolic Process Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Mitochondrial Fragmentation Involved In Apoptotic Process Transcytosis Negative Regulation Of Inflammatory Response Positive Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Mitochondrial Fission Mitochondrion To Lysosome Transport Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Negative Regulation Of Neuron Death Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Dendritic Spine Maintenance Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Presynapse Assembly Retrograde Transport, Endosome To Plasma Membrane Regulation Of Terminal Button Organization
Pathways		WNT ligand biogenesis and trafficking Ub-specific processing proteases	WNT ligand biogenesis and trafficking
Drugs		S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS
Interacting Genes		12 interacting genes: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 RAB7A RPRM SCNN1A STX11 TSC22D2 USP10 VPS35	12 interacting genes: APP DRD1 LINC01554 MTNR1B SLC11A2 SNX1 SNX3 VEGFA VPS26A VPS26B VPS29 ZNF512B
Entrez ID		8724	55737
HPRD ID		09333	06085
Ensembl ID		ENSG00000112335	ENSG00000069329
Uniprot IDs		O60493	Q96QK1
PDB IDs		2MXC 2YPS 5F0J 5F0L 5F0M 5F0P	2R17 5F0J 5F0K 5F0L 5F0M 5F0P 5OSH 5OSI
Enriched GO Terms of Interacting Partners?
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