USP10 and G3BP1

Data Source:
BioGRID (proximity labelling technology, proximity labelling technology)
HPRD (in vitro, in vivo)

		USP10	G3BP1
Description		ubiquitin specific peptidase 10	G3BP stress granule assembly factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Protein-containing Complex Intermediate Filament Cytoskeleton	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Perikaryon Ribonucleoprotein Complex
	Molecular Function	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Ion Channel Binding	DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding Endonuclease Activity Protein Binding ATP Binding DNA/RNA Helicase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Autophagy Cellular Response To DNA Damage Stimulus Regulation Of Autophagy Protein Deubiquitination Protein Phosphopantetheinylation Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1	Ras Protein Signal Transduction Viral Process DNA Duplex Unwinding Type I Interferon Production Stress Granule Assembly Innate Immune Response Defense Response To Virus Positive Regulation Of Stress Granule Assembly Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Termination of translesion DNA synthesis Ub-specific processing proteases
Drugs
Diseases
GWAS		Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		16 interacting genes: AR G3BP1 G3BP2 H2AC20 IKBKG MSH2 NOTCH1 PRKAA2 RACK1 RAD51 SCNN1A SCNN1G SIRT6 SMAD4 SNX3 UBC	12 interacting genes: APP CSK DTX1 EPHA8 FBXO25 IL7R LCK LINC01554 PIN1 PPIA RASA1 USP10
Entrez ID		9100	10146
HPRD ID		07029	06569
Ensembl ID		ENSG00000103194	ENSG00000145907
Uniprot IDs		Q14694	Q13283 Q5U0Q1 Q6ZP53
PDB IDs			3Q90 4FCJ 4FCM 4IIA 5FW5
Enriched GO Terms of Interacting Partners?
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