VPS35 and VPS26A

Data Source:
BioGRID (two hybrid)

		VPS35	VPS26A
Description		VPS35 retromer complex component	VPS26, retromer complex component A
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GO Annotations	Cellular Component	Mitochondrion Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Retromer Complex Retromer, Cargo-selective Complex Extracellular Exosome Tubular Endosome Mitochondrion-derived Vesicle	Lysosome Endosome Early Endosome Cytosol Endosome Membrane Retromer Complex Retromer, Cargo-selective Complex Vesicle Tubular Endosome
	Molecular Function	Protein Binding D1 Dopamine Receptor Binding	Protein Binding
	Biological Process	Intracellular Protein Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Viral Process Wnt Signaling Pathway Regulation Of Macroautophagy Regulation Of Protein Stability Regulation Of Cellular Protein Metabolic Process Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Mitochondrial Fragmentation Involved In Apoptotic Process Transcytosis Negative Regulation Of Inflammatory Response Positive Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Mitochondrial Fission Mitochondrion To Lysosome Transport Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Negative Regulation Of Neuron Death Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Dendritic Spine Maintenance Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Presynapse Assembly Retrograde Transport, Endosome To Plasma Membrane Regulation Of Terminal Button Organization	Intracellular Protein Transport Wnt Signaling Pathway Regulation Of Macroautophagy Retrograde Transport, Endosome To Golgi Retrograde Transport, Endosome To Plasma Membrane
Pathways		WNT ligand biogenesis and trafficking	WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS			Body size at age 10 ( 32376654) Glycemic traits (pregnancy) ( 23903356) Immune reponse to smallpox (secreted IL-1beta) ( 22610502) Type 2 diabetes ( 21874001 30718926)
Interacting Genes		12 interacting genes: APP DRD1 LINC01554 MTNR1B SLC11A2 SNX1 SNX3 VEGFA VPS26A VPS26B VPS29 ZNF512B	4 interacting genes: MORF4L1 RAB7A VPS35 ZSCAN12
Entrez ID		55737	9559
HPRD ID		06085	08385
Ensembl ID		ENSG00000069329	ENSG00000122958
Uniprot IDs		Q96QK1	B4DLT1 O75436
PDB IDs		2R17 5F0J 5F0K 5F0L 5F0M 5F0P 5OSH 5OSI	2FAU 5F0J 5F0L 5F0M 5F0P
Enriched GO Terms of Interacting Partners?
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