SNX4 and BIN1

Data Source:
HPRD (two hybrid, in vivo)

		SNX4	BIN1
Description		sorting nexin 4	bridging integrator 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoplasmic Dynein Complex Plasma Membrane Membrane SNARE Complex Early Endosome Membrane Protein-containing Complex	Nucleus Nuclear Envelope Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon Dendrite I Band Vesicle Node Of Ranvier Axon Initial Segment Lipid Tube
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding	Protease Binding Protein Binding Phospholipid Binding Aspartic-type Endopeptidase Inhibitor Activity Clathrin Binding Identical Protein Binding Tau Protein Binding Actin Filament Binding Chaperone Binding RNA Polymerase Binding
	Biological Process	Protein Transport Endocytic Recycling Positive Regulation Of Histamine Secretion By Mast Cell	Endocytosis Nucleus Organization Cytoskeleton Organization Endosome To Lysosome Transport Viral Process Regulation Of Endocytosis Positive Regulation Of Actin Filament Polymerization T-tubule Organization Positive Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Nucleus Localization Lipid Tube Assembly Membrane Organization Regulation Of Cell Cycle Arrest Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways			Clathrin-mediated endocytosis
Drugs
Diseases			Centronuclear myopathy
GWAS		Adult body size ( 32376654) Estimated glomerular filtration rate in non-diabetics ( 31451708) Urate levels ( 31578528)	Alzheimer's disease ( 22832961 21460840 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 21390209 30617256 24162737 28714976) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) Creatine kinase levels ( 29403010) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411) Neurofibrillary tangles ( 25188341) Neutrophil count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Psychosis and Alzheimer's disease ( 22005930) Systemic lupus erythematosus ( 24871463)
Interacting Genes		18 interacting genes: AGK ARL6IP1 ATP6V0A1 BIN1 DGAT2L6 EGFR HIVEP1 INSR LEPR MAGEA6 PDGFRA PDGFRB PTPN5 SH3GLB1 SNX2 SNX6 SNX7 SUPT5H	46 interacting genes: ABL1 ACTA1 ACTG1 AMPH AP2A1 AP2A2 APP APPL1 ASAP2 ATXN2 CLIP1 CUX1 DLGAP4 DNM1 DNM2 E2F1 FBP1 FHL2 ITCH ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PLD1 PLD2 PTGER4 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNAPIN SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC WASL XRCC4 ZBTB3
Entrez ID		8723	274
HPRD ID		09334	03150
Ensembl ID		ENSG00000114520	ENSG00000136717
Uniprot IDs		O95219	A0A024RAE9 A0A024RAF0 A0A024RAF1 A0A024RAF6 A0A024RAG8 A0A024RAG9 A0A024RAI4 A0A024RAI5 A0A024RAI6 A0A024RAJ2 A0A024RAJ3 B7Z2Z2 B7Z6Y2 O00499 Q9BTH3
PDB IDs			1MUZ 1MV0 1MV3 2FIC 2RMY 2RND 5I22
Enriched GO Terms of Interacting Partners?
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