KRT37 and FBXW5

Data Source:
BioGRID (two hybrid)

		KRT37	FBXW5
Description		keratin 37	F-box and WD repeat domain containing 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Extracellular Exosome	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Structural Molecule Activity Protein Binding	Protein Binding Protein Kinase Binding
	Biological Process	Keratinization Cornification	Protein Polyubiquitination Regulation Of Mitotic Nuclear Division Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways		Keratinization Formation of the cornified envelope	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Squamous cell lung carcinoma ( 28604730)	Blood protein levels ( 29875488) Heel bone mineral density ( 30598549) Plateletcrit ( 32888494)
Interacting Genes		41 interacting genes: AGXT AQP1 BCAS2 BFSP2 C21orf58 CCDC196 CLCNKA COL8A1 DES FAM110A FBXW5 GNG13 HAPLN2 HGS HOXA1 HSF4 KRT1 KRT3 KRT4 KRT6B KRT6C KRT71 KRT74 KRT75 KRT76 KRT81 KRT83 KRT85 KRT86 MTG1 NUFIP2 OIP5 OTX1 PIN1 PKN1 PSMA1 SMARCD1 SMARCE1 TBC1D21 TXLNB USHBP1	35 interacting genes: ADAMTSL4 CYSRT1 EFEMP2 FAM168A FBLN2 KRT31 KRT34 KRT37 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-1 KRTAP4-12 KRTAP6-3 KRTAP9-3 KRTAP9-4 MDFI MID2 MTUS2 MYB NBPF19 NLK NOTCH2NLA PLEKHF2 S100B SASS6 SEC23B SKP1 TRIM27 TSC2 UBE2R2 VWC2
Entrez ID		8688	54461
HPRD ID		05175	10955
Ensembl ID		ENSG00000108417	ENSG00000159069
Uniprot IDs		O76014	A0A024R8H7 Q969U6
PDB IDs
Enriched GO Terms of Interacting Partners?
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