FBXW5 and VWC2

Data Source:
BioGRID (two hybrid)

		FBXW5	VWC2
Description		F-box and WD repeat domain containing 5	von Willebrand factor C domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Basement Membrane Interstitial Matrix Extracellular Space AMPA Glutamate Receptor Complex Synapse
	Molecular Function	Protein Binding Protein Kinase Binding	Molecular_function Protein Binding
	Biological Process	Protein Polyubiquitination Regulation Of Mitotic Nuclear Division Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification	Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Neuron Differentiation
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Heel bone mineral density ( 30598549) Plateletcrit ( 32888494)	Blood protein levels ( 30072576 29875488) Body mass index ( 28892062 25673413) Lung cancer in never smokers ( 28604730) Neurological blood protein biomarker levels ( 31320639) Post bronchodilator FEV1/FVC ratio ( 26634245) Pursuit maintenance gain ( 29064472) Serum thyroid-stimulating hormone levels ( 25436638)
Interacting Genes		35 interacting genes: ADAMTSL4 CYSRT1 EFEMP2 FAM168A FBLN2 KRT31 KRT34 KRT37 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-1 KRTAP4-12 KRTAP6-3 KRTAP9-3 KRTAP9-4 MDFI MID2 MTUS2 MYB NBPF19 NLK NOTCH2NLA PLEKHF2 S100B SASS6 SEC23B SKP1 TRIM27 TSC2 UBE2R2 VWC2	57 interacting genes: ABHD15 ADAMTSL4 ATPAF2 CAMLG CATSPER1 CNNM3 CRY2 CYSRT1 ENKD1 FAM90A1 FBXW5 FUCA2 GET3 GNE HAPLN2 HOXA1 HPCA HPCAL1 KANK2 KPRP KRTAP10-8 KRTAP13-2 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 LCE1A LCE1C LCE1F LCE2C LCE2D LCE3A LCE3D LCE3E LCE4A NTM OTX1 PFKFB1 POU4F2 PRPF31 SCNM1 SGTB SHFL SPRY1 TRAPPC14 UBQLN1 UBQLN2 VASN YY1 ZNF319 ZNF417 ZNF490 ZNF497 ZNF587 ZNF696 ZNF774 ZNF837
Entrez ID		54461	375567
HPRD ID		10955	18271
Ensembl ID		ENSG00000159069	ENSG00000188730
Uniprot IDs		A0A024R8H7 Q969U6	Q2TAL6
PDB IDs
Enriched GO Terms of Interacting Partners?
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