DYNLL1 and NTRK3

Data Source:
HPRD (in vivo)

		DYNLL1	NTRK3
Description		dynein light chain LC8-type 1	neurotrophic receptor tyrosine kinase 3
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GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium COP9 Signalosome Membrane Dynein Complex Tertiary Granule Membrane Mitotic Spindle Ciliary Tip Ficolin-1-rich Granule Membrane Axon Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Axon Receptor Complex
	Molecular Function	Motor Activity Enzyme Inhibitor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Scaffold Protein Binding	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Spermatid Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Macroautophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Intraciliary Retrograde Transport Intraciliary Transport Involved In Cilium Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Neutrophil Degranulation Motile Cilium Assembly Negative Regulation Of Nitric Oxide Biosynthetic Process Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed	Activation Of MAPK Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Positive Chemotaxis Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Receptor-type tyrosine-protein phosphatases NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K NTRK3 as a dependence receptor
Drugs			Entrectinib Fostamatinib Larotrectinib Pralsetinib
Diseases			Neuroblastoma
GWAS		High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Gaucher disease severity ( 22388998) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		107 interacting genes: ACTB ACTC1 ACTG1 ALDOA AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C12orf40 C14orf119 C19orf44 CA2 CACNB1 CCDC28A CLIP2 CS DAZ1 DCTN5 DLG4 DLGAP1 DNAJB9 DNAL4 DNM2 DNM3 DNMT1 DPPA3 DYNC1H1 DYNC1I1 EEF1A1 ERG28 FAM117B FAM153A FAM53B GABARAPL1 GABARAPL2 GAPDH GLUD1 GLUL GNL3L GPHN GPRIN2 GRIN3A HIP1R HMBOX1 HOMER3 HSPA8 IHO1 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MORN3 MRE11 MTA1 MTR MYO10 MYO5A NDEL1 NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 ODF3 OR7C2 OTUD6A PAK1 PAN2 PARD3 PAX6 PCM1 PFKM PFKP PKIA PKIB PKIG POLH PPP3R2 RAB4A RACK1 RASGRP4 RGS2 SHROOM3 SLC13A1 SMCP TERT THAP10 THAP8 TNFRSF14 TP53BP1 TRIM54 TSNARE1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A ZNF710	28 interacting genes: APP BEX3 DOK5 DOK6 DYNLL1 ERBB2 FRS2 HEY1 HTR2A IRAK1 IRAK3 JUN KIDINS220 KPNA4 MAPK1 MAPK3 NELFB NGFR NSD1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SORT1 SQSTM1 WDR13
Entrez ID		8655	4916
HPRD ID		03334	01870
Ensembl ID		ENSG00000088986	ENSG00000140538
Uniprot IDs		P63167 Q6FGH9	B7Z7U4 O95193 Q16288 Q96CY4 X5D2R1 X5D7M5 X5DNW6
PDB IDs		1CMI 3ZKE 3ZKF 6GZJ 6GZL 6RLB 6SC2	1WWC 3V5Q 4YMJ 6KZC 6KZD
Enriched GO Terms of Interacting Partners?
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