DYNLL1 and SHROOM3

Data Source:
HPRD (in vitro)

		DYNLL1	SHROOM3
Description		dynein light chain LC8-type 1	shroom family member 3
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium COP9 Signalosome Membrane Dynein Complex Tertiary Granule Membrane Mitotic Spindle Ciliary Tip Ficolin-1-rich Granule Membrane Axon Cytoplasm	Cytoskeleton Microtubule Adherens Junction Apical Plasma Membrane Cortical Actin Cytoskeleton Apical Junction Complex
	Molecular Function	Motor Activity Enzyme Inhibitor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Scaffold Protein Binding	Actin Filament Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Spermatid Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Macroautophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Intraciliary Retrograde Transport Intraciliary Transport Involved In Cilium Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Neutrophil Degranulation Motile Cilium Assembly Negative Regulation Of Nitric Oxide Biosynthetic Process Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed	Cell Morphogenesis Neural Tube Closure Epithelial Cell Development Actin Filament Organization Pattern Specification Process Regulation Of Cell Shape Cellular Pigment Accumulation Apical Protein Localization
Pathways		Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Alanine transaminase levels ( 29403010) Blood urea nitrogen levels ( 31152163) Cardiometabolic and hematological traits ( 27668658) Chronic kidney disease ( 31152163 26831199 20383146) Cleft lip with or without cleft palate ( 28054174) Coronary artery disease ( 29212778) Craniofacial microsomia ( 26853712) Creatinine levels ( 31015462 29403010 20383145) Estimated glomerular filtration rate ( 31152163 31015462 31451708 29124443 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 23535967 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gut microbiota (bacterial taxa) ( 27723756) Hematocrit ( 32888494 27863252 24777453) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Magnesium levels ( 20700443 26058915) Metabolite levels (small molecules and protein measures) ( 27005778) Microalbuminuria ( 31511532) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Pulse pressure ( 27841878) Red blood cell count ( 32888494 27863252) Renal function and chronic kidney disease ( 19430482) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549 32154731) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		107 interacting genes: ACTB ACTC1 ACTG1 ALDOA AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C12orf40 C14orf119 C19orf44 CA2 CACNB1 CCDC28A CLIP2 CS DAZ1 DCTN5 DLG4 DLGAP1 DNAJB9 DNAL4 DNM2 DNM3 DNMT1 DPPA3 DYNC1H1 DYNC1I1 EEF1A1 ERG28 FAM117B FAM153A FAM53B GABARAPL1 GABARAPL2 GAPDH GLUD1 GLUL GNL3L GPHN GPRIN2 GRIN3A HIP1R HMBOX1 HOMER3 HSPA8 IHO1 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MORN3 MRE11 MTA1 MTR MYO10 MYO5A NDEL1 NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 ODF3 OR7C2 OTUD6A PAK1 PAN2 PARD3 PAX6 PCM1 PFKM PFKP PKIA PKIB PKIG POLH PPP3R2 RAB4A RACK1 RASGRP4 RGS2 SHROOM3 SLC13A1 SMCP TERT THAP10 THAP8 TNFRSF14 TP53BP1 TRIM54 TSNARE1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A ZNF710	1 interacting genes: DYNLL1
Entrez ID		8655	57619
HPRD ID		03334	07053
Ensembl ID		ENSG00000088986	ENSG00000138771
Uniprot IDs		P63167 Q6FGH9	B3KY47 Q8TF72
PDB IDs		1CMI 3ZKE 3ZKF 6GZJ 6GZL 6RLB 6SC2	6FBB 6FCP
Enriched GO Terms of Interacting Partners?
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