SSNA1 and SPAST

Data Source:
HPRD (two hybrid, in vivo)

		SSNA1	SPAST
Description		SS nuclear autoantigen 1	spastin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Centrosome Cytosol Ciliary Basal Body	Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Centrosome Spindle Cytosol Microtubule Microtubule Cytoskeleton Integral Component Of Membrane Midbody Cytoplasmic Vesicle Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Axon Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Isomerase Activity ATPase Activity Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Intraciliary Transport Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Ciliary Basal Body-plasma Membrane Docking	Mitotic Cytokinesis Microtubule Bundle Formation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Axonogenesis Anterograde Axonal Transport Metabolic Process Exit From Mitosis Axonal Transport Of Mitochondrion Positive Regulation Of Microtubule Depolymerization Cytoplasmic Microtubule Organization Nuclear Envelope Reassembly Positive Regulation Of Cytokinesis Cytokinetic Process Protein Hexamerization Microtubule Severing Mitotic Spindle Disassembly Protein Homooligomerization Cytoskeleton-dependent Cytokinesis Membrane Fission
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS			Apolipoprotein A1 levels ( 32203549) Bisphosphonate-associated atypical femoral fracture ( 31006051) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		12 interacting genes: CDC37 EHHADH LNX1 NTAQ1 PICK1 PSMC5 RNF4 SDCBP SPAST TBC1D7 TCEANC TXN2	4 interacting genes: CHMP1B IST1 RTN1 SSNA1
Entrez ID		8636	6683
HPRD ID		10251	05044
Ensembl ID		ENSG00000176101	ENSG00000021574
Uniprot IDs		A0A024R8G6 O43805	E5KRP5 E5KRP6 Q9UBP0
PDB IDs			3EAB 3VFD 5Z6Q 5Z6R 6PEK 6PEN
Enriched GO Terms of Interacting Partners?
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