RUNX1T1 and UBQLN4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RUNX1T1	UBQLN4
Description		RUNX1 partner transcriptional co-repressor 1	ubiquilin 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Matrix	Nucleus Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Membrane Cytosol Cytoplasmic Vesicle Nuclear Proteasome Complex Cytosolic Proteasome Complex Protein-containing Complex Perinuclear Region Of Cytoplasm Site Of DNA Damage
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Metal Ion Binding	Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated	DNA Repair Ubiquitin-dependent Protein Catabolic Process Autophagy Cellular Response To DNA Damage Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Autophagosome Maturation Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Drugs
Diseases		Acute myeloid leukemia (AML)
GWAS		Adult body size ( 32376654) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Number of sexual partners ( 30643258) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Plasma anti-thyroglobulin levels ( 29678681) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Crohn's disease ( 28067908) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		100 interacting genes: ABI3 ADAMTSL4 ARHGAP9 ATN1 BCL6 BIRC2 BRCA1 BRME1 CBFA2T3 CBY2 CCDC197 CDC23 CDR2 CEP170P1 CEP83 COG6 CPSF7 CREB3L1 DEUP1 DNMT1 EFHC2 EPS8 ETS1 FAM136A FAM9A GFI1 GSE1 HDAC1 HDAC3 HDAC8 HOMER3 HOXB2 HSP90AA1 ID1 ID3 IHO1 KIAA0408 KIFC3 KPNA1 KPNB1 KRT23 KRT27 KRT33B KRT35 KRTAP13-3 KRTAP19-6 KRTAP6-2 KRTAP6-3 LHX3 LPXN LZTS1 LZTS2 MEOX2 MID2 NCOR1 NCOR2 NECAB2 NEUROG1 OIP5 PCBD2 PIAS2 PLSCR3 PRDM14 PRDM16 PRDM6 PRKAR1B PRKAR2A RAD54L2 REL RNF4 RTN4IP1 SH3RF1 SIN3A SORBS3 SPEN SPRY2 STX11 SYCE1 TAF9B TAL2 TCF12 TCF3 TCF4 TEKT1 TFIP11 TRIM42 TRIM54 UBQLN4 VDR VPS52 WBP11 XIAP ZBTB16 ZFP36 ZFP90 ZMAT1 ZMYM4 ZNF343 ZNF652 ZNF655	161 interacting genes: ADAM33 ADPGK AGR2 ANKRD13D AREG ARL4C ATP5IF1 ATP5MK ATXN1 BAG6 BPIFA1 C11orf49 C1orf94 C1QTNF1 CACNA1G CCDC107 CCDC134 CCDC136 CCDC14 CCDC33 CCL21 CD99 CDSN CEND1 COL8A1 COPB1 CPSF6 CRIPT CSTF2 CSTF2T CTSB CYB5R1 DAZAP2 DKK3 DMPK DNAJB11 DTX2 EAPP EDN1 EEF1A1 EFEMP2 ELF5 EPDR1 ERP27 ERP29 FA2H FGFBP1 FKBP2 FKBP7 FZD7 GABRD GDI1 GJA1 GJA5 GJC1 GKAP1 GPX7 HAVCR1 HGS HK2 HSPA13 HSPA5 IGFBP6 IGHM IGLC1 IMMT IMPDH2 ITPRIPL1 KLHL26 KLHL42 LAT2 MDK MDM2 MIEF2 MIF4GD MLLT6 MOAP1 MTNR1B MYDGF NAE1 NME3 NOMO1 NOMO3 NOTCH2NLA NPHP1 NPPA NXF1 OAT ORC5 PBXIP1 PCDH17 PCDH8 PDIA5 PDLIM7 PELI2 PICK1 PIN1 PIP4K2B PLAAT3 PMEPA1 PNMA1 PPIB PPIC PRL PRPF40A PTN PTPRN PTPRN2 QSOX1 RAD23A RAI2 RBM10 RIC8A RNF11 RNPS1 ROBO2 RPN1 RSRC2 RUNX1T1 RXRA SCAF1 SCG2 SCG5 SCMH1 SEMG1 SERPINE1 SERPINH1 SERPINI2 SMAD3 SMAD9 SMARCB1 SPAG8 SPINT1 SPP1 SRGN SRSF2 STAM2 STMN1 SUPT20H TFF1 TGFB1I1 TNFRSF14 TNRC6B TRAF2 TRIB2 TRIM32 UBC UBQLN1 UBQLN2 UBR7 UNC119 UROS VIP WAC YWHAQ ZBTB22 ZDHHC3 ZFPM2 ZG16 ZG16B ZNF205
Entrez ID		862	56893
HPRD ID		00590	05670
Ensembl ID		ENSG00000079102	ENSG00000160803
Uniprot IDs		A0A087WWT6 A0A0A0MSU1 B2R6I9 Q06455 W8FW32	B4DZF6 Q59F94 Q9NRR5
PDB IDs		1WQ6 2DJ8 2H7B 2KNH 2KYG 2OD1 2ODD 2PP4 4JOL
Enriched GO Terms of Interacting Partners?
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