RUVBL1 and MRGBP

Data Source:
HPRD (in vitro)

		RUVBL1	MRGBP
Description		RuvB like AAA ATPase 1	MRG domain binding protein
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GO Annotations	Cellular Component	Swr1 Complex Nucleus Nucleoplasm Microtubule Organizing Center Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Exosome MLL1 Complex R2TP Complex Ribonucleoprotein Complex	Nucleoplasm NuA4 Histone Acetyltransferase Complex
	Molecular Function	TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Coactivator Activity Protein Binding ATP Binding ATPase Activity TBP-class Protein Binding 5'-3' DNA Helicase Activity ADP Binding Cadherin Binding ATPase Binding	Protein Binding
	Biological Process	Box C/D SnoRNP Assembly DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cell Cycle Spermatogenesis Histone Acetylation Protein Deubiquitination DNA Duplex Unwinding CENP-A Containing Nucleosome Assembly Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Positive Regulation Of Telomerase RNA Localization To Cajal Body	Regulation Of Transcription By RNA Polymerase II Histone Acetylation Regulation Of Growth
Pathways		Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones UCH proteinases Ub-specific processing proteases DNA Damage Recognition in GG-NER Deposition of new CENPA-containing nucleosomes at the centromere	HATs acetylate histones
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Gestational age at birth (maternal effect) ( 28877031) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		20 interacting genes: ACTL6A CEP126 CTNNB1 DKC1 FBL LZTR1 MRGBP MYC NEDD4 OFD1 PLG RUVBL2 STOM SUMO2 TAF9 TBP TERT TK1 YY1 ZNHIT2	25 interacting genes: ACTB ACTL6A BRD8 DAPK1 DMAP1 HSPB1 ING1 KRTAP1-1 KRTAP10-7 KRTAP17-1 KRTAP5-7 LRRK2 MEAF6 MFHAS1 MORF4L1 MORF4L2 MSL1 NBPF19 NOTCH2NLA RUVBL1 SH3BP4 TRRAP TUBB VAV2 YEATS4
Entrez ID		8607	55257
HPRD ID		09143	16646
Ensembl ID		ENSG00000175792	ENSG00000101189
Uniprot IDs		A0A384MTR5 B3KRS7 E7ETR0 Q9Y265	Q9NV56
PDB IDs		2C9O 2XSZ 5OAF 6FO1 6HTS 6IGM 6K0R 6QI8 6QI9	2N1D
Enriched GO Terms of Interacting Partners?
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