RUVBL1 and ZNHIT2

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid)

		RUVBL1	ZNHIT2
Description		RuvB like AAA ATPase 1	zinc finger HIT-type containing 2
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GO Annotations	Cellular Component	Swr1 Complex Nucleus Nucleoplasm Microtubule Organizing Center Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Exosome MLL1 Complex R2TP Complex Ribonucleoprotein Complex
	Molecular Function	TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Coactivator Activity Protein Binding ATP Binding ATPase Activity TBP-class Protein Binding 5'-3' DNA Helicase Activity ADP Binding Cadherin Binding ATPase Binding	Protein Binding Metal Ion Binding
	Biological Process	Box C/D SnoRNP Assembly DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cell Cycle Spermatogenesis Histone Acetylation Protein Deubiquitination DNA Duplex Unwinding CENP-A Containing Nucleosome Assembly Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones UCH proteinases Ub-specific processing proteases DNA Damage Recognition in GG-NER Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Gestational age at birth (maternal effect) ( 28877031) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		20 interacting genes: ACTL6A CEP126 CTNNB1 DKC1 FBL LZTR1 MRGBP MYC NEDD4 OFD1 PLG RUVBL2 STOM SUMO2 TAF9 TBP TERT TK1 YY1 ZNHIT2	5 interacting genes: CD2BP2 JAKMIP1 KRTAP22-1 LONRF1 RUVBL1
Entrez ID		8607	741
HPRD ID		09143	05200
Ensembl ID		ENSG00000175792	ENSG00000174276
Uniprot IDs		A0A384MTR5 B3KRS7 E7ETR0 Q9Y265	Q9UHR6
PDB IDs		2C9O 2XSZ 5OAF 6FO1 6HTS 6IGM 6K0R 6QI8 6QI9	1X4S
Enriched GO Terms of Interacting Partners?
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