KHSRP and GCC1

Data Source:
BioGRID (affinity chromatography technology)

		KHSRP	GCC1
Description		KH-type splicing regulatory protein	GRIP and coiled-coil domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Golgi Trans Cisterna Golgi Membrane Golgi Apparatus Cytosol
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding	Protein Binding Small GTPase Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Regulation Of Transcription, DNA-templated MRNA Processing RNA Splicing Regulation Of Gene Expression MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	Retrograde transport at the Trans-Golgi-Network
Drugs		Resveratrol Artenimol
Diseases
GWAS			Feeling worry ( 29500382) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Medication adherence in chronic diseases ( 25317111) Refractive error ( 32231278) Type 2 diabetes ( 26818947 22158537 30718926)
Interacting Genes		14 interacting genes: A1CF APBB1 BACE1 EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 KLHL12 PARN PTBP2 STK3 UBE2I	64 interacting genes: ABI2 AMOTL2 APP ARL1 ATF4 ATN1 BIRC2 BRCA1 C1orf94 CCDC33 CCDC85B CEP57 CEP70 COIL CPSF7 DISC1 DNAJA3 FAM83A FBF1 FBXO28 FIGNL1 FOSL1 GAS8 GLI1 GOLGA2 GTF2I HDX ICA1L IKBKG ITSN1 KATNAL1 KDM1A KIAA0753 KIAA1217 KIF5B LCA5 LZTS2 MCRS1 MED4 MEOX1 MID2 NAB2 NAV1 NECAB2 NINL OIP5 PAK5 PPP1R18 PPP1R27 PRPF18 RUNX1 SMARCD1 SPOP TFIP11 TLE5 TP53BP2 TRIM29 TRIM50 USHBP1 UTP14C XIAP ZC4H2 ZFP90 ZNF276
Entrez ID		8570	79571
HPRD ID		10350	07599
Ensembl ID		ENSG00000088247	ENSG00000179562
Uniprot IDs		Q92945	A4D0Z4 Q96CN9
PDB IDs		2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T
Enriched GO Terms of Interacting Partners?
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