GCC1 and PAK5

Data Source:
BioGRID (two hybrid)

		GCC1	PAK5
Description		GRIP and coiled-coil domain containing 1	p21 (RAC1) activated kinase 5
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Trans Cisterna Golgi Membrane Golgi Apparatus Cytosol	Nucleoplasm Cytoplasm Mitochondrion Synapse
	Molecular Function	Protein Binding Small GTPase Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process		Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cell Migration Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Retrograde transport at the Trans-Golgi-Network	Activation of RAC1
Drugs			Fostamatinib
Diseases
GWAS		Feeling worry ( 29500382) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Medication adherence in chronic diseases ( 25317111) Refractive error ( 32231278) Type 2 diabetes ( 26818947 22158537 30718926)	Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)
Interacting Genes		64 interacting genes: ABI2 AMOTL2 APP ARL1 ATF4 ATN1 BIRC2 BRCA1 C1orf94 CCDC33 CCDC85B CEP57 CEP70 COIL CPSF7 DISC1 DNAJA3 FAM83A FBF1 FBXO28 FIGNL1 FOSL1 GAS8 GLI1 GOLGA2 GTF2I HDX ICA1L IKBKG ITSN1 KATNAL1 KDM1A KIAA0753 KIAA1217 KIF5B LCA5 LZTS2 MCRS1 MED4 MEOX1 MID2 NAB2 NAV1 NECAB2 NINL OIP5 PAK5 PPP1R18 PPP1R27 PRPF18 RUNX1 SMARCD1 SPOP TFIP11 TLE5 TP53BP2 TRIM29 TRIM50 USHBP1 UTP14C XIAP ZC4H2 ZFP90 ZNF276	34 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 TSGA10 TUBGCP4 UXT
Entrez ID		79571	57144
HPRD ID		07599	06423
Ensembl ID		ENSG00000179562	ENSG00000101349
Uniprot IDs		A4D0Z4 Q96CN9	B0AZM9 Q9P286
PDB IDs			2F57
Enriched GO Terms of Interacting Partners?
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