PKP4 and CDH1

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		PKP4	CDH1
Description		plakophilin 4	cadherin 1
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cornified Envelope Nucleus Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Cytoplasmic Side Of Plasma Membrane Cell Junction Desmosome Midbody Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle	Extracellular Region Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Integral Component Of Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Cortical Actin Cytoskeleton Apical Junction Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Cadherin Binding	Calcium Ion Binding Protein Binding Beta-catenin Binding Ankyrin Binding GTPase Activating Protein Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding
	Biological Process	Cell-cell Junction Assembly Cell-cell Signaling Regulation Of Cell Adhesion Keratinization Positive Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Cornification Cell-cell Adhesion	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Response To Toxic Substance Regulation Of Gene Expression Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Negative Regulation Of Cell Migration Neuron Projection Development Adherens Junction Organization Entry Of Bacterium Into Host Cell Positive Regulation Of Protein Import Into Nucleus Response To Drug Positive Regulation Of Transcription, DNA-templated Cellular Response To Lithium Ion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Pathways		Keratinization Formation of the cornified envelope	Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells
Drugs
Diseases			Gastric cancer Penile cancer Nasopharyngeal cancer Breast cancer Hepatocellular carcinoma Thyroid cancer
GWAS		Borderline personality disorder ( 28632202) Obesity-related traits ( 23251661) Restless legs syndrome ( 29029846)	Colorectal cancer ( 19011631) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 32341527 26237428) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Late-onset Alzheimer's disease ( 27770636) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Nevus count or cutaneous melanoma ( 32341527) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Ulcerative colitis ( 19915572)
Interacting Genes		19 interacting genes: ATPAF2 CDH1 CDH2 CDH5 DSC3 DSP ERBIN GABARAP GOLGA2 LNX1 LZTS2 MINK1 OSGEP PAXIP1 PDZD2 PGAM1 PSEN1 TRIM23 UBASH3B	67 interacting genes: ACTR3 AKT1 ANAPC7 AOPEP ARHGAP32 ARVCF CA9 CASP3 CASP8 CBLL1 CDC42 CDK8 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 EGFR ERBIN EZR FER FGFR1 FYN GALNT12 GNA12 GNA13 GSK3B HDAC1 HDAC2 HEMGN HRAS HSD17B3 IQGAP1 IRS1 ITGAE ITGB7 JUP KEAP1 MAD2L2 MAP2K1 MAPK3 MDM2 MSANTD3 MYO6 NANS NDRG1 NEDD9 NFE2L2 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM RAB8B RRM2 SFRP2 SKP2 STX17 TMOD1 UCHL3 VCL YES1 ZNF510
Entrez ID		8502	999
HPRD ID		05043	01885
Ensembl ID		ENSG00000144283	ENSG00000039068
Uniprot IDs		Q99569	A0A0U2ZQU7 B3GN61 P12830 Q9UII7
PDB IDs			1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y 4ZT1 4ZTE 6CXY 6OLE 6OLF 6OLG 6VEL
Enriched GO Terms of Interacting Partners?
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