TRIM55 and MYC

Data Source:
BioGRID (two hybrid)

		TRIM55	MYC
Description		tripartite motif containing 55	MYC proto-oncogene, bHLH transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule	Chromatin Nucleus Nucleoplasm Nucleolus Protein-containing Complex
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Activating Transcription Factor Binding Protein-containing Complex Binding Protein Dimerization Activity Repressing Transcription Factor Binding E-box Binding
	Biological Process	Leukocyte Migration Involved In Inflammatory Response Signal Transduction Protein Ubiquitination Diapedesis Macrophage Migration	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Energy Reserve Metabolic Process Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cellular Iron Ion Homeostasis Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Notch Signaling Pathway Positive Regulation Of Cell Population Proliferation Response To Gamma Radiation Regulation Of Gene Expression Positive Regulation Of Gene Expression Oxygen Transport Protein Deubiquitination Cytokine-mediated Signaling Pathway Regulation Of Telomere Maintenance Negative Regulation Of Stress-activated MAPK Cascade Protein-DNA Complex Disassembly Cellular Response To UV Cellular Response To Drug Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Fibroblast Apoptotic Process Negative Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Epithelial Cell Proliferation Chromosome Organization Negative Regulation Of Cell Division Positive Regulation Of Telomerase Activity ERK1 And ERK2 Cascade Response To Growth Factor Cellular Response To Hypoxia Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Regulation Of Somatic Stem Cell Population Maintenance Beta-catenin-TCF Complex Assembly Positive Regulation Of DNA Methylation Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus
Pathways			Transcription of E2F targets under negative control by DREAM complex NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Binding of TCF/LEF:CTNNB1 to target gene promoters MAPK6/MAPK4 signaling Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry TFAP2 (AP-2) family regulates transcription of cell cycle factors RUNX3 regulates WNT signaling Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis
Drugs			Acetylsalicylic acid Nadroparin
Diseases			Choriocarcinoma Penile cancer Burkitt lymphoma Oral cancer Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Multiple myeloma Small cell lung cancer Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Osteosarcoma Kaposi's sarcoma Laryngeal cancer Breast cancer Ovarian cancer
GWAS		Coronary heart disease event reduction (statin therapy interaction) ( 22666496) Metabolite levels ( 23823483) Recurrent major depressive disorder ( 29317602)	Alcohol use disorder ( 30940813) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 31036433 30929738) Bladder cancer ( 20972438) Breast cancer ( 29059683 23535729) Chronic lymphocytic leukemia ( 23770605) Colorectal cancer ( 25990418 26151821 24737748 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diffuse large B cell lymphoma ( 25261932) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Glioblastoma ( 29743610) Glioma ( 29743610) Height ( 25429064) Multiple sclerosis ( 21833088) Non-glioblastoma glioma ( 29743610) Nonsyndromic cleft lip with cleft palate ( 28232668) Ovarian cancer ( 23535730 20852632) Pancreatic cancer ( 29422604 27579533 25086665) Prostate cancer ( 24753544) Prostate cancer (early onset) ( 24740154) Prostate-specific antigen levels ( 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Renal cell carcinoma ( 24220699) Urinary bladder cancer ( 20348956 18794855 24861552)
Interacting Genes		310 interacting genes: ACBD4 ACD ACTA1 ADAMTSL4 AEBP2 AFM AGO2 AKR1C8P ALKBH3 ANKRD1 ANKRD39 APLN APOBEC4 ARL6IP4 ATG4D ATP5F1B ATP5F1D ATXN3 ATXN3L ATXN7L1 BCAT1 BCHE BRAP BRD4 BRWD1 BTBD9 BYSL C10orf88 C12orf4 C1orf35 C3orf36 C8orf74 CADPS CAMK2A CAPN3 CARS1 CBX2 CCDC120 CCDC130 CCDC28B CDK3 CDS2 CENPK CHMP7 CKM COA7 COX4I1 CRCT1 CTAG1A CTAG1B CTNNB1 CTSF CYB5R2 CYP46A1 CYTOR DAPL1 DCAF11 DCAF6 DCTN3 DECR2 DEF8 DEK DES DNTTIP1 DOCK7 DYNLT2B EED EEF1G EHHADH EIF3E ELAPOR1 EPS8L2 ESPL1 EZH2 FAM185A FAM90A1 FANK1 FASTKD1 FHL2 FKBP6 FLNA FLNB FLNC FRMD6 FYN GABPB1 GATA3 GFM1 GLI4 GMEB1 GOLGA2P5 GPRIN2 GPS1 GRB10 GRB14 HID1 HIRA HOXA1 HROB HSPB1 ID1 IFI35 IGF2 IK IL37 ILF3 INCA1 ING4 INKA1 IQUB IRF2 IRF3 ITGB5 JADE3 KBTBD4 KCTD15 KIAA0087 KIAA0408 KIF13A KIF1B KIF5A KLHDC4 KLHL36 KMT2B KYAT1 LAGE3 LAMTOR5 LAPTM4A LIMS2 LINC00518 LINC00663 LINC00905 LINC01588 LMCD1 LMO2 LRRC56 LYN LYNX1 MAGEC3 MALSU1 MAP3K14 MBD4 MBIP MCM7 MDM4 MIDN MIIP MKI67 MLH3 MLLT11 MPP1 MPZL1 MRPL19 MRPL20-AS1 MRPL41 MSRB3 MYBPC1 MYBPC3 MYBPHL MYC MYCT1 MYOT MYOZ1 NDUFA1 NDUFA8 NEB NEBL NEFL NGEF NOMO1 NR1D2 NR2C2 NSD3 NSUN7 NUFIP2 ODF2 OGFOD2 OTUB1 OTUB2 P3H3 PACRGL PAFAH1B2 PCGF1 PCGF3 PCGF6 PELI3 PELO PHC2 PHF23 PIAS1 PIAS2 PIAS3 PIP4K2B PKM PLEKHG4 PLXNA3 POLD1 POLR2E PPARA PPIE PRKAB2 PRKACA PRR30 PRRT1 PYGM RABEPK RAD23A RAI2 RBM14 RELA REX1BD RGR RHEB RHPN1 RING1 RNF10 RNF114 RPS4X RRAS RUSC1 RUSC1-AS1 SEC23B SET SHFL SLC6A13 SLFN12 SNW1 SPATS1 SPRYD7 SPSB1 SPSB2 SQSTM1 STAM SYMPK SYNCRIP TCAP TCP10L TEX19 THAP3 TIGD5 TIMM17B TMBIM1 TMEM35A TNIP3 TNNI1 TNNI2 TNNI3 TOR1AIP2 TPD52L3 TRAF3IP2 TRIB3 TRIM23 TRIM27 TRIM35 TRIM41 TRIM54 TRIM63 TRIM69 TRMT10B TSC2 TSC22D4 TTN TUBGCP4 UBA3 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2L3 UCHL3 UCHL5 UNKL USP13 USP28 USP4 USP5 USP7 USP8 UXT VAC14 VPS37A WT1 XAGE1B YOD1 YPEL3 ZBTB14 ZBTB17 ZC2HC1C ZC3H12A ZC3HC1 ZFYVE19 ZNF124 ZNF20 ZNF302 ZNF333 ZNF345 ZNF431 ZNF436 ZNF460 ZNF566 ZNF57 ZNF581 ZNF597 ZNF649 ZNF653 ZNF667-AS1 ZNF767P ZNF775 ZNF83 ZSCAN16	178 interacting genes: ACTL6A AKT1 APP ARAF ARNT ATAD2 AURKA AXIN1 BCL2 BIN1 BRCA1 BRD3 BTRC CALM1 CBLC CCAR2 CCNE1 CCNT1 CDC6 CDC73 CDCA7L CDK1 CDK4 CDK6 CDK8 CDK9 CDKN1B CDKN2A CDKN2B CDKN2C CEBPA CEBPB CEP57 CIP2A CREBBP CSNK2A1 CSNK2A2 DACH1 DNMT3A EFNB1 ELF3 EP300 EP400 EPHA2 ERBB2 FBXO8 FBXW7 FBXW8 FGFR4 FZR1 GCN1 GLIS1 GLIS2 GPX2 GRM1 GSK3A GSK3B GTF2F1 GTF2F2 GTF2I HGF HIF1A HSP90AA1 ING4 KAT2A KAT2B KAT5 KDELR2 KDM1A KIDINS220 LATS2 LDOC1 MAP2K1 MAP2K5 MAPK1 MAPK14 MAPK3 MAPK7 MAPK8 MAX MDM2 MED1 MED16 MEN1 MET MLH1 MOK MSH2 MXD1 MXI1 MYCBP MYCBP2 NDRG1 NEK11 NF2 NFIC NFYB NFYC NMI NONO NOTCH3 NSD3 NUCB1 PAK2 PARP10 PDGFRA PFDN5 PIK3CA PLAU PLK1 PML PPP2CA PRDX1 PSMC3 PTEN RAF1 RASSF1 RB1 RBL1 RELA RIOX2 RUVBL1 RUVBL2 SAP130 SENP2 SF3B1 SKP1 SKP2 SMAD2 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SNIP1 SNRNP70 SOX3 SOX4 SP1 SPAG9 STK11 SUPT3H TADA2A TAF12 TAF1B TAF9 TBP TEAD2 TERT TFAP2A TFAP2B TIAM1 TONSL TP53 TP73 TRIM55 TRIM6 TRIM63 TRRAP TSC1 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 UBB USP2 USP22 USP36 USP37 USP7 VDR WT1 YAF2 YBX1 YY1 ZBTB17 ZNF281
Entrez ID		84675	4609
HPRD ID		05927	01818
Ensembl ID		ENSG00000147573	ENSG00000136997
Uniprot IDs		Q9BYV6	P01106
PDB IDs			1A93 1EE4 1MV0 1NKP 2A93 2OR9 4Y7R 5I4Z 5I50 6C4U 6E16 6E24 6G6J 6G6K 6G6L
Enriched GO Terms of Interacting Partners?
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