MYC and PLK1

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, proximity labelling technology)

		MYC	PLK1
Description		MYC proto-oncogene, bHLH transcription factor	polo like kinase 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Protein-containing Complex	Kinetochore Chromatin Synaptonemal Complex Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody Centriolar Satellite Spindle Midzone Mitotic Spindle Pole
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Activating Transcription Factor Binding Protein-containing Complex Binding Protein Dimerization Activity Repressing Transcription Factor Binding E-box Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Anaphase-promoting Complex Binding Kinase Activity Protein Kinase Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Energy Reserve Metabolic Process Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cellular Iron Ion Homeostasis Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Notch Signaling Pathway Positive Regulation Of Cell Population Proliferation Response To Gamma Radiation Regulation Of Gene Expression Positive Regulation Of Gene Expression Oxygen Transport Protein Deubiquitination Cytokine-mediated Signaling Pathway Regulation Of Telomere Maintenance Negative Regulation Of Stress-activated MAPK Cascade Protein-DNA Complex Disassembly Cellular Response To UV Cellular Response To Drug Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Fibroblast Apoptotic Process Negative Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Epithelial Cell Proliferation Chromosome Organization Negative Regulation Of Cell Division Positive Regulation Of Telomerase Activity ERK1 And ERK2 Cascade Response To Growth Factor Cellular Response To Hypoxia Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Regulation Of Somatic Stem Cell Population Maintenance Beta-catenin-TCF Complex Assembly Positive Regulation Of DNA Methylation Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Cytokinesis Microtubule Bundle Formation Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Sister Chromatid Cohesion Mitotic Nuclear Envelope Disassembly Mitotic Spindle Assembly Checkpoint Centrosome Cycle Regulation Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Peptidyl-threonine Phosphorylation Female Meiosis Chromosome Segregation Protein Ubiquitination Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Regulation Of Protein Binding Homologous Chromosome Segregation Establishment Of Protein Localization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Proteolysis Nuclear Envelope Disassembly Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Synaptonemal Complex Disassembly Protein Localization To Chromatin Signal Transduction Involved In G2 DNA Damage Checkpoint Protein Localization To Nuclear Envelope Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Spindle Assembly Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Protein Localization To Cell Cortex
Pathways		Transcription of E2F targets under negative control by DREAM complex NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Binding of TCF/LEF:CTNNB1 to target gene promoters MAPK6/MAPK4 signaling Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry TFAP2 (AP-2) family regulates transcription of cell cycle factors RUNX3 regulates WNT signaling Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase Mitotic Metaphase/Anaphase Transition Mitotic Telophase/Cytokinesis Cyclin A/B1/B2 associated events during G2/M transition The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs		Acetylsalicylic acid Nadroparin	3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE 1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea Wortmannin Fostamatinib
Diseases		Choriocarcinoma Penile cancer Burkitt lymphoma Oral cancer Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Multiple myeloma Small cell lung cancer Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Osteosarcoma Kaposi's sarcoma Laryngeal cancer Breast cancer Ovarian cancer
GWAS		Alcohol use disorder ( 30940813) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 31036433 30929738) Bladder cancer ( 20972438) Breast cancer ( 29059683 23535729) Chronic lymphocytic leukemia ( 23770605) Colorectal cancer ( 25990418 26151821 24737748 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diffuse large B cell lymphoma ( 25261932) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Glioblastoma ( 29743610) Glioma ( 29743610) Height ( 25429064) Multiple sclerosis ( 21833088) Non-glioblastoma glioma ( 29743610) Nonsyndromic cleft lip with cleft palate ( 28232668) Ovarian cancer ( 23535730 20852632) Pancreatic cancer ( 29422604 27579533 25086665) Prostate cancer ( 24753544) Prostate cancer (early onset) ( 24740154) Prostate-specific antigen levels ( 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Renal cell carcinoma ( 24220699) Urinary bladder cancer ( 20348956 18794855 24861552)	Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494)
Interacting Genes		178 interacting genes: ACTL6A AKT1 APP ARAF ARNT ATAD2 AURKA AXIN1 BCL2 BIN1 BRCA1 BRD3 BTRC CALM1 CBLC CCAR2 CCNE1 CCNT1 CDC6 CDC73 CDCA7L CDK1 CDK4 CDK6 CDK8 CDK9 CDKN1B CDKN2A CDKN2B CDKN2C CEBPA CEBPB CEP57 CIP2A CREBBP CSNK2A1 CSNK2A2 DACH1 DNMT3A EFNB1 ELF3 EP300 EP400 EPHA2 ERBB2 FBXO8 FBXW7 FBXW8 FGFR4 FZR1 GCN1 GLIS1 GLIS2 GPX2 GRM1 GSK3A GSK3B GTF2F1 GTF2F2 GTF2I HGF HIF1A HSP90AA1 ING4 KAT2A KAT2B KAT5 KDELR2 KDM1A KIDINS220 LATS2 LDOC1 MAP2K1 MAP2K5 MAPK1 MAPK14 MAPK3 MAPK7 MAPK8 MAX MDM2 MED1 MED16 MEN1 MET MLH1 MOK MSH2 MXD1 MXI1 MYCBP MYCBP2 NDRG1 NEK11 NF2 NFIC NFYB NFYC NMI NONO NOTCH3 NSD3 NUCB1 PAK2 PARP10 PDGFRA PFDN5 PIK3CA PLAU PLK1 PML PPP2CA PRDX1 PSMC3 PTEN RAF1 RASSF1 RB1 RBL1 RELA RIOX2 RUVBL1 RUVBL2 SAP130 SENP2 SF3B1 SKP1 SKP2 SMAD2 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SNIP1 SNRNP70 SOX3 SOX4 SP1 SPAG9 STK11 SUPT3H TADA2A TAF12 TAF1B TAF9 TBP TEAD2 TERT TFAP2A TFAP2B TIAM1 TONSL TP53 TP73 TRIM55 TRIM6 TRIM63 TRRAP TSC1 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 UBB USP2 USP22 USP36 USP37 USP7 VDR WT1 YAF2 YBX1 YY1 ZBTB17 ZNF281	120 interacting genes: - ACTL6B APP ASPM BAG6 BCL2L1 BIRC6 BRCA2 BUB1 BUB1B C6orf136 CCDC115 CCNB1 CDC14A CDC25C CENPQ CEP55 CHEK2 CSN1S1 CSN2 CTNNB1 DNAJB9 DNHD1 ECT2 EIF6 FBXL5 FBXW7 FZR1 GET4 GLB1 GORASP1 IKBKB INTS11 ITSN1 KIF23 KIF2C KLF4 KLHL22 KRBA1 LMO4 LRP5L LRRK1 LRRK2 MAD2L1BP MAGED1 MCM2 MCM3 MCM7 MDM2 MPP2 MYC MYT1 NEDD4 NHSL2 NINL NPM1 NUDC PARP10 PHC2 PIN1 PITPNM1 PKMYT1 PLK3 PPID PRC1 PRKN PSMA1 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PTEN PTPRD RABAC1 RACGAP1 RAD51 RAP1GAP RECQL5 RELA REST RGCC RICTOR RNF126 RNF2 RXRA SIMC1 SNCA SNCB SPOUT1 SREBF1 STAG2 STK3 STUB1 SUGT1 TANK TNFSF11 TOP2A TP53 TP53BP2 TP73 TPT1 TRIOBP TSC1 TUBA4A TUBB TUBB3 TUBG1 USP16 USP7 VRK3 WEE1 ZNF71
Entrez ID		4609	5347
HPRD ID		01818	03652
Ensembl ID		ENSG00000136997	ENSG00000166851
Uniprot IDs		P01106	P53350
PDB IDs		1A93 1EE4 1MV0 1NKP 2A93 2OR9 4Y7R 5I4Z 5I50 6C4U 6E16 6E24 6G6J 6G6K 6G6L	1Q4K 1Q4O 1UMW 2OGQ 2OJX 2OU7 2OWB 2RKU 2V5Q 2YAC 3BZI 3C5L 3FC2 3FVH 3HIH 3HIK 3KB7 3P2W 3P2Z 3P34 3P35 3P36 3P37 3Q1I 3RQ7 3THB 4A4L 4A4O 4DFW 4E67 4E9C 4E9D 4H5X 4H71 4HAB 4HCO 4HY2 4J52 4J53 4LKL 4LKM 4O56 4O6W 4O9W 4RCP 4WHH 4WHK 4WHL 4X9R 4X9V 4X9W 5J19 5NEI 5NFU 5NJE 5NMM 5NN1 5NN2 5TA6 5TA8 6AX4 6GY2
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?