GLIS2 and PRR20E

Data Source:
BioGRID (two hybrid)

		GLIS2	PRR20E
Description		GLIS family zinc finger 2	proline rich 20E
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Non-motile Cilium
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter Involved In Kidney Development Cell Differentiation Involved In Kidney Development Hematopoietic Stem Cell Homeostasis Positive Regulation Of Protein Localization To Nucleus
Pathways
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Erectile dysfunction ( 30583798) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 26635082) Prostate-specific antigen levels ( 28139693)	Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		92 interacting genes: ACTN3 AKAP9 AKT1 ANKRD36B ARAF ARID5A ARNT BCAR1 BECN1 C19orf54 CBLC CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CPSF1 CREM CRX CSNK2B CTBP2 CTNNB1 EPHA2 ERBB2 FAM168B FGFR4 FOSB FZR1 GLIS1 GMNN GOLGA6L9 GPSM1 GPSM2 HGF HIF1A KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP8-1 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MDM2 MDM4 MET MYC NF2 NFIC NME7 NSD3 OIP5 PIK3CA PLEKHB1 PLEKHB2 POU6F2 PRKAR1B PRR20A PRR20B PRR20C PRR20D PRR20E RAF1 RASSF1 RBFOX2 RBM11 RBPMS SHOX SOX3 SPECC1L STK11 TEAD2 TENT5A TERT TLE5 TRIM32 TSC1 TWIST2 U2AF2 VAC14 VBP1 VENTX WNK1 WT1 WWOX XAB2 ZRANB1	89 interacting genes: ABI2 ANKHD1 ARID5A ATXN1 BANP BEND2 BHLHE40 BICRAL C10orf55 C1orf94 C3orf36 CABP2 CCNK CDC37 CELF4 DAZAP2 DMRT3 DVL3 EIF4ENIF1 ESRP1 FAM168A FAM222B FAM9A FOXH1 FOXP3 GLIS2 GTF2A1 HIVEP1 HLX HYPK KRTAP19-1 KRTAP19-5 LASP1 MAGED1 MBNL3 NCK2 NFYC NOTCH3 NTAQ1 OXER1 PATZ1 PHF1 PITX1 POGZ POU2F1 POU6F2 PRR20A PRR20B PRR20C PRR20D PRR34 PRR35 PTTG2 RBM23 RBM42 RBPMS RBPMS2 RHOXF2 RIPPLY1 RNF4 ROR2 SAMD11 SH3RF1 SIAH1 SMAP1 SNRPB SNRPC SP4 SRPK2 TBX3 TBX6 TCF7L2 TFG THAP1 TIAL1 TLX3 TOLLIP TPRX1 TRIM35 VAC14 VENTX VEZF1 VPS37C YPEL3 ZBTB32 ZC3H10 ZCCHC14 ZNF385C ZNF683
Entrez ID		84662	729250
HPRD ID		12256	19671
Ensembl ID		ENSG00000126603	ENSG00000234278
Uniprot IDs		B3KTH4 Q9BZE0	P86478 P86479 P86480 P86481 P86496
PDB IDs
Enriched GO Terms of Interacting Partners?
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