GLIS2 and KRTAP19-5

Data Source:
BioGRID (two hybrid)

		GLIS2	KRTAP19-5
Description		GLIS family zinc finger 2	keratin associated protein 19-5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Non-motile Cilium	Cytosol Intermediate Filament
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter Involved In Kidney Development Cell Differentiation Involved In Kidney Development Hematopoietic Stem Cell Homeostasis Positive Regulation Of Protein Localization To Nucleus	Keratinization
Pathways			Keratinization
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Erectile dysfunction ( 30583798) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 26635082) Prostate-specific antigen levels ( 28139693)
Interacting Genes		92 interacting genes: ACTN3 AKAP9 AKT1 ANKRD36B ARAF ARID5A ARNT BCAR1 BECN1 C19orf54 CBLC CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CPSF1 CREM CRX CSNK2B CTBP2 CTNNB1 EPHA2 ERBB2 FAM168B FGFR4 FOSB FZR1 GLIS1 GMNN GOLGA6L9 GPSM1 GPSM2 HGF HIF1A KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP8-1 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MDM2 MDM4 MET MYC NF2 NFIC NME7 NSD3 OIP5 PIK3CA PLEKHB1 PLEKHB2 POU6F2 PRKAR1B PRR20A PRR20B PRR20C PRR20D PRR20E RAF1 RASSF1 RBFOX2 RBM11 RBPMS SHOX SOX3 SPECC1L STK11 TEAD2 TENT5A TERT TLE5 TRIM32 TSC1 TWIST2 U2AF2 VAC14 VBP1 VENTX WNK1 WT1 WWOX XAB2 ZRANB1	97 interacting genes: ANKHD1 APOBEC1 ARID5A ATN1 ATPAF2 BHLHE40 C11orf16 C9orf24 CAMK2A CAMK2B CATSPER1 CCDC17 CELF5 CHRD COL8A1 CRACR2A CREB5 CRYAB CYSRT1 DAB1 DAZAP2 DMRT3 DMRTB1 EFEMP2 ENKD1 ESRP1 EVX2 FAM168A FAM214B GLIS2 GLYCTK GPANK1 GRINA GUCD1 HAPLN2 HGS HOXB9 HYPK INCA1 KIFC3 KPRP KRT34 KRTAP12-4 KRTAP15-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 MAGED1 MAPK1IP1L MGAT5B MYOZ3 MYPOP OIP5 OLIG3 OXER1 P4HA3 PATZ1 PITX1 PITX2 PLSCR4 POU2AF1 PPP1R16A PPP1R32 PRKAG3 PRPF31 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 PSMB2 PSMB4 RBPMS RBPMS2 RHOXF2 RNF38 RNF44 RTP5 RUSC1 SEMA3B SNRPC SOHLH1 TCF7L2 TEKT3 TEX37 TLE5 TNIP1 TSPYL6 UBQLN2 VAC14 VEZF1 VPS37C ZBTB32 ZIC1 ZNF414
Entrez ID		84662	337972
HPRD ID		12256	11209
Ensembl ID		ENSG00000126603	ENSG00000186977
Uniprot IDs		B3KTH4 Q9BZE0	Q3LI72
PDB IDs
Enriched GO Terms of Interacting Partners?
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