CASR and RNF19A

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro)

		CASR	RNF19A
Description		calcium sensing receptor	ring finger protein 19A, RBR E3 ubiquitin protein ligase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Neuronal Cell Body Axon Terminus	Ubiquitin Ligase Complex Cytoplasm Centrosome Cytosol Integral Component Of Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Integrin Binding Calcium Ion Binding Protein Binding Amino Acid Binding Protein Kinase Binding Protein Homodimerization Activity Ion Channel Binding	Protein Binding Transcription Factor Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ossification Response To Ischemia Detection Of Calcium Ion Cellular Calcium Ion Homeostasis Apoptotic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway JNK Cascade Chemosensory Behavior Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Positive Regulation Of ATPase Activity Bile Acid Secretion Cellular Response To Hepatocyte Growth Factor Stimulus Vasodilation Positive Regulation Of Vasoconstriction Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Regulation Of Calcium Ion Transport Fat Pad Development Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Import Cellular Response To Vitamin D Cellular Response To Glucose Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hypoxia Response To Fibroblast Growth Factor Positive Regulation Of Calcium Ion Import Cellular Response To Peptide Chloride Transmembrane Transport	Protein Polyubiquitination Microtubule Cytoskeleton Organization Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Pathways		G alpha (q) signalling events G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Spermine Neomycin Cinacalcet Ronacaleret NPS-2143 Calcium citrate Calcium Phosphate Etelcalcetide Calcium phosphate dihydrate
Diseases		Bartter syndrome
GWAS		Calcium levels ( 20661308 25972035 25886283 24068962 29403010 20705733) Cardiac Troponin-T levels ( 23247143) Clinical laboratory measurements ( 27897004) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Kidney stones ( 26272126) Metabolite levels ( 31628463) Phosphorus levels ( 20558539) Psoriasis ( 25854761) QT interval ( 29874175) Serum parathyroid hormone levels ( 27927781) Type 2 diabetes ( 32499647 30718926)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Atrioventricular conduction ( 21041692) Recurrent major depressive disorder ( 29317602)
Interacting Genes		11 interacting genes: FLNA GRM1 HIF1A NOTCH1 PI4K2B PRKCA PRKCB PRKCG RNF19A STAMBP VHL	17 interacting genes: C11orf58 CASR ILK MAP3K20 MAP3K7 NUDT21 RPS6KA5 SNCAIP SOD1 SUFU TUBG1 TUBG2 UBE2D2 UBE2E2 UBE2L3 UBE2L6 VCP
Entrez ID		846	25897
HPRD ID		03122	06176
Ensembl ID		ENSG00000036828	ENSG00000034677
Uniprot IDs		P41180	Q9NV58
PDB IDs		5FBH 5FBK 5K5S 5K5T
Enriched GO Terms of Interacting Partners?
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