SYVN1 and UBE2U

Data Source:
BioGRID (two hybrid)

		SYVN1	UBE2U
Description		synoviolin 1	ubiquitin conjugating enzyme E2 U
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GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment	HULC Complex
	Molecular Function	Protein Binding Metal Ion Binding Unfolded Protein Binding Chaperone Binding ATPase Binding Ubiquitin Protein Ligase Activity Ubiquitin-specific Protease Binding	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Immature B Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol IRE1-mediated Unfolded Protein Response ERAD Pathway Protein Stabilization Protein K48-linked Ubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Mannose Trimming	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		XBP1(S) activates chaperone genes Hedgehog ligand biogenesis Hh mutants are degraded by ERAD ER Quality Control Compartment (ERQC)	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 32581322)	Severe bacterial meningitis ( 31092817)
Interacting Genes		13 interacting genes: APP ATN1 CLU ERN1 GPR37 TP53 UBE2D2 UBE2D3 UBE2G1 UBE2U UBE2Z USP15 USP7	68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		84447	148581
HPRD ID		07618	14599
Ensembl ID		ENSG00000162298	ENSG00000177414
Uniprot IDs		Q86TM6	A0A140VJY9 Q5VVX9
PDB IDs		6A3Z	1YRV
Enriched GO Terms of Interacting Partners?
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