POLR1B and MED20

Data Source:
BioGRID (two hybrid)

		POLR1B	MED20
Description		RNA polymerase I subunit B	mediator complex subunit 20
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex Cytosol	Ubiquitin Ligase Complex Nucleoplasm Mediator Complex
	Molecular Function	DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Ribonucleoside Binding Metal Ion Binding	Transcription Coactivator Activity DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Embryo Implantation RRNA Transcription Nucleologenesis Positive Regulation Of Gene Expression, Epigenetic	Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 20139978 27863252) Mean corpuscular volume ( 23263863 20139978 27863252) Metabolite levels ( 23823483) Red blood cell count ( 20139978)
Interacting Genes		14 interacting genes: AKT2 CCND1 EIF3L ESR1 GIT2 HDAC6 LDB1 LZTR1 MED20 NFKBIB POLR1E RPL37 RRN3 ZNF207	16 interacting genes: ANKS1A CD300C CYB5R2 ERP27 ESR1 ESR2 GABPB1 MARK4 MED18 MED29 MED8 PIH1D2 POLR1B PSORS1C2 TRIM69 YY1
Entrez ID		84172	9477
HPRD ID		06852	15638
Ensembl ID		ENSG00000125630	ENSG00000124641
Uniprot IDs		B7Z1W6 Q9H9Y6	B3KUJ9 Q9H944
PDB IDs
Enriched GO Terms of Interacting Partners?
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