MED20 and MED18

Data Source:
HPRD (in vivo, in vitro)

		MED20	MED18
Description		mediator complex subunit 20	mediator complex subunit 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Mediator Complex	Ubiquitin Ligase Complex Mediator Complex Core Mediator Complex
	Molecular Function	Transcription Coactivator Activity DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated	Regulation Of Transcription By RNA Polymerase II Termination Of RNA Polymerase II Transcription Protein Ubiquitination
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978 27863252) Mean corpuscular volume ( 23263863 20139978 27863252) Metabolite levels ( 23823483) Red blood cell count ( 20139978)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)
Interacting Genes		16 interacting genes: ANKS1A CD300C CYB5R2 ERP27 ESR1 ESR2 GABPB1 MARK4 MED18 MED29 MED8 PIH1D2 POLR1B PSORS1C2 TRIM69 YY1	9 interacting genes: AFMID CAMK2B HOMEZ MED20 MED31 MED9 TEPSIN TRIM39 USP49
Entrez ID		9477	54797
HPRD ID		15638	17476
Ensembl ID		ENSG00000124641	ENSG00000130772
Uniprot IDs		B3KUJ9 Q9H944	Q9BUE0
PDB IDs
Enriched GO Terms of Interacting Partners?
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