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ATRIP and CDC6
Data Source:
BioGRID
(pull down)
ATRIP
CDC6
Description
ATR interacting protein
cell division cycle 6
Image
GO Annotations
Cellular Component
Nucleoplasm
Spindle Pole
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Intercellular Bridge
Spindle Midzone
Mitotic Spindle
Molecular Function
Protein Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Nucleotide Binding
DNA Replication Origin Binding
Protein Binding
ATP Binding
Kinase Binding
Biological Process
DNA Damage Checkpoint
DNA Replication
DNA Repair
Interstrand Cross-link Repair
Regulation Of Signal Transduction By P53 Class Mediator
DNA Replication Checkpoint
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
DNA Replication Initiation
Traversing Start Control Point Of Mitotic Cell Cycle
Negative Regulation Of DNA Replication
Negative Regulation Of Cell Population Proliferation
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of Cytokinesis
Mitotic DNA Replication Checkpoint
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Fibroblast Proliferation
Cell Division
Positive Regulation Of Chromosome Segregation
Cellular Response To Vasopressin
Cellular Response To Angiotensin
Pathways
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Transcription of E2F targets under negative control by DREAM complex
Activation of ATR in response to replication stress
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
Drugs
Diseases
GWAS
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Asthma (
31619474
)
Interacting Genes
22 interacting genes:
BRCA1
C1orf94
CCDC28B
CDC23
CDC6
CDK16
CEP164
CINP
FAAP100
FAM156A
LNX1
METTL21A
MID2
MOS
MX2
POLR1C
PRKDC
RPA3
SCG2
SPRY2
TASOR2
ZBTB14
38 interacting genes:
AKAP8L
ATM
ATRIP
B3GALNT1
CCNA2
CCNB1
CCNE1
CCNF
CDC14A
CDC20
CDK1
CDK2
CDK4
CDK6
CDKN1A
CDKN2A
CDT1
FZR1
KAT7
MCM10
MCM2
MCM3
MCM7
MYC
ORC1
ORC2
ORC3
ORC5
ORC6
PCNA
PPP2R3A
PPP2R3B
PSKH1
RPS27A
SQSTM1
TERF1
UBE2K
UBR1
Entrez ID
84126
990
HPRD ID
04022
Ensembl ID
ENSG00000164053
ENSG00000094804
Uniprot IDs
A0A024R2U4
A0A024R307
Q8WXE1
A0A024R1S2
Q99741
PDB IDs
4IGK
4NB3
5YZ0
2CCH
2CCI
4I5L
4I5N
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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