ATRIP and CCDC28B

Data Source:
BioGRID (two hybrid)

		ATRIP	CCDC28B
Description		ATR interacting protein	coiled-coil domain containing 28B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Cytoplasm Centrosome
	Molecular Function	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding
	Biological Process	DNA Damage Checkpoint DNA Replication DNA Repair Interstrand Cross-link Repair Regulation Of Signal Transduction By P53 Class Mediator	Cilium Assembly
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		22 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP FAAP100 FAM156A LNX1 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SPRY2 TASOR2 ZBTB14	10 interacting genes: APP ARMC7 ATRIP ENKD1 GRB2 PRKAB2 SCNM1 TRIM55 TRIM63 UBL5
Entrez ID		84126	79140
HPRD ID			14422
Ensembl ID		ENSG00000164053	ENSG00000160050
Uniprot IDs		A0A024R2U4 A0A024R307 Q8WXE1	Q9BUN5
PDB IDs		4IGK 4NB3 5YZ0
Enriched GO Terms of Interacting Partners?
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