ATRIP and TASOR2

Data Source:
BioGRID (two hybrid)

		ATRIP	TASOR2
Description		ATR interacting protein	transcription activation suppressor family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Nucleoplasm Cytosol
	Molecular Function	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding
	Biological Process	DNA Damage Checkpoint DNA Replication DNA Repair Interstrand Cross-link Repair Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		22 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP FAAP100 FAM156A LNX1 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SPRY2 TASOR2 ZBTB14	49 interacting genes: ARMC7 ATRIP BHLHB9 C1orf109 CARD9 CCDC33 CCDC85B CCNG2 CFAP206 COX5B CTNNA3 ERH FBF1 GPSM1 HGS HSF2BP KCTD9 KIFC3 KLHL40 LDOC1 LMO1 LONRF1 MDFI MEOX2 MID2 MKRN3 MLH1 MORN3 NEK6 PACRGL PIH1D2 PIK3R3 PNMA1 POLR1C PPP1R16B PRKAB2 PRKAR1B RFC5 SCAMP1 SERTAD3 SMARCB1 STAT3 TRIM23 TRIM42 TRIM73 TSEN15 USHBP1 YPEL3 ZNF76
Entrez ID		84126	54906
HPRD ID			10695
Ensembl ID		ENSG00000164053	ENSG00000108021
Uniprot IDs		A0A024R2U4 A0A024R307 Q8WXE1	Q5VWN6
PDB IDs		4IGK 4NB3 5YZ0
Enriched GO Terms of Interacting Partners?
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