HTRA1 and IMPDH1

Data Source:
BioGRID (two hybrid)

		HTRA1	IMPDH1
Description		HtrA serine peptidase 1	inosine monophosphate dehydrogenase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Nucleus Cytoplasm Cytosol Secretory Granule Lumen Azurophil Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Insulin-like Growth Factor Binding Serine-type Peptidase Activity Identical Protein Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Metal Ion Binding
	Biological Process	Placenta Development Proteolysis Extracellular Matrix Disassembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Defense Response To Virus Chorionic Trophoblast Cell Differentiation Dentinogenesis	GMP Biosynthetic Process GTP Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation
Pathways		Degradation of the extracellular matrix	Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS
Drugs			NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine 6-Chloropurine Riboside, 5'-Monophosphate VX-148 Taribavirin
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)	Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23455636 23536807 20861866 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Age-related macular degeneration (wet) ( 17053108) Coronary artery disease ( 29212778 33020668) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Diverticular disease ( 30177863) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Laterality in neovascular age-related macular degeneration ( 28775256) Lung function (FEV1/FVC) ( 30061609 30804560) Migraine ( 27322543) Neovascular age-related macular degeneration ( 28703135) Refractive error ( 32231278) Stroke ( 29531354) Systolic blood pressure ( 30224653 30578418)	Pelvic organ prolapse ( 32184442)
Interacting Genes		22 interacting genes: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM107A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 LTBP1 MAPT NOS3 PARD6B RPS6KA1 TENT5A XIAP	8 interacting genes: DDIT4L GMNN HTRA1 IMPDH2 PIAS2 RAD54L2 RNF4 UBE2I
Entrez ID		5654	3614
HPRD ID		03725	08853
Ensembl ID		ENSG00000166033	ENSG00000106348
Uniprot IDs		Q92743	B3KRZ3 P20839 Q6ZNB1
PDB IDs		2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ	1JCN
Enriched GO Terms of Interacting Partners?
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