HTRA1 and BMP4

Data Source:
HPRD (in vitro)

		HTRA1	BMP4
Description		HtrA serine peptidase 1	bone morphogenetic protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Insulin-like Growth Factor Binding Serine-type Peptidase Activity Identical Protein Binding	Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Co-receptor Binding Chemoattractant Activity BMP Receptor Binding
	Biological Process	Placenta Development Proteolysis Extracellular Matrix Disassembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Defense Response To Virus Chorionic Trophoblast Cell Differentiation Dentinogenesis	Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPKK Activity Osteoblast Differentiation Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Neural Tube Closure Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Renal System Process BMP Signaling Pathway Involved In Heart Induction Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Muscular Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Right Ventricle Morphogenesis Apoptotic Process Involved In Endocardial Cushion Morphogenesis Cardiac Septum Development Type B Pancreatic Cell Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Common-partner SMAD Protein Phosphorylation Germ Cell Development Endoderm Development Mesodermal Cell Fate Determination Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Post-embryonic Development Anterior/posterior Axis Specification Specification Of Animal Organ Position Regulation Of Cell Fate Commitment Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cell Death Telencephalon Development Dorsal/ventral Neural Tube Patterning Telencephalon Regionalization Pituitary Gland Development Erythrocyte Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Binding Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Tendon Cell Differentiation Deltoid Tuberosity Development Regulation Of Protein Import Into Nucleus Negative Regulation Of Phosphorylation Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Intermediate Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Smooth Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Fiber Development Inner Ear Receptor Cell Differentiation Cloacal Septation Lens Induction In Camera-type Eye Embryonic Skeletal Joint Morphogenesis Cranial Suture Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Lung Morphogenesis Bronchus Development Trachea Development Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Prostate Gland Morphogenesis Bud Elongation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis Bud Dilation Involved In Lung Branching Negative Regulation Of Cell Death Mammary Gland Formation Epithelial-mesenchymal Cell Signaling Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Coronary Vasculature Development Positive Regulation Of Cartilage Development Positive Regulation Of Branching Involved In Lung Morphogenesis BMP Signaling Pathway Involved In Ureter Morphogenesis BMP Signaling Pathway Involved In Renal System Segmentation Pulmonary Artery Endothelial Tube Morphogenesis BMP Signaling Pathway Involved In Heart Development Pharyngeal Arch Artery Morphogenesis Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To BMP Stimulus BMP Signaling Pathway Involved In Nephric Duct Formation Glomerular Visceral Epithelial Cell Development Negative Regulation Of Branch Elongation Involved In Ureteric Bud Branching By BMP Signaling Pathway Specification Of Ureteric Bud Anterior/posterior Symmetry By BMP Signaling Pathway Glomerular Capillary Formation Negative Regulation Of Glomerular Mesangial Cell Proliferation Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesenchymal Cell Differentiation Involved In Kidney Development Ureter Epithelial Cell Differentiation Ureter Smooth Muscle Cell Differentiation Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Metanephric Collecting Duct Development Positive Regulation Of Kidney Development Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Glomerulus Development Positive Regulation Of Cell Proliferation Involved In Outflow Tract Morphogenesis Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Cardiac Jelly Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Degradation of the extracellular matrix	Molecules associated with elastic fibres Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Calcium
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)	Anophthalmia and microphthalmia (A/M)
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23455636 23536807 20861866 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Age-related macular degeneration (wet) ( 17053108) Coronary artery disease ( 29212778 33020668) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Diverticular disease ( 30177863) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Laterality in neovascular age-related macular degeneration ( 28775256) Lung function (FEV1/FVC) ( 30061609 30804560) Migraine ( 27322543) Neovascular age-related macular degeneration ( 28703135) Refractive error ( 32231278) Stroke ( 29531354) Systolic blood pressure ( 30224653 30578418)	Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Colorectal cancer ( 25990418 19011631 26151821) Colorectal cancer or advanced adenoma ( 30510241) Dental caries ( 23259602) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) Heel bone mineral density ( 30598549 28869591) High myopia ( 31816047) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Logical memory (delayed recall) in normal cognition ( 29274321) Lung function (FEV1/FVC) ( 30804560) Monobrow thickness ( 26926045) Myopia ( 27182965) Optic cup area ( 25631615) Optic disc size ( 31809533) Parkinson's disease ( 19915575) Peak expiratory flow ( 30804560) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for body mass index ( 27195708)
Interacting Genes		22 interacting genes: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM107A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 LTBP1 MAPT NOS3 PARD6B RPS6KA1 TENT5A XIAP	18 interacting genes: ACVR2A BGN BMP8B BMPER BMPR1A BMPR1B BMPR2 CHRDL1 CHRDL2 GREM2 HTRA1 NOG RGMB SOSTDC1 STAP2 TDGF1 TWSG1 ZFYVE9
Entrez ID		5654	652
HPRD ID		03725	00207
Ensembl ID		ENSG00000166033	ENSG00000125378
Uniprot IDs		Q92743	P12644 Q53XC5
PDB IDs		2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ
Enriched GO Terms of Interacting Partners?
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