SMC1A and SMC3

Data Source:
HPRD (in vivo)

		SMC1A	SMC3
Description		structural maintenance of chromosomes 1A	structural maintenance of chromosomes 3
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Mitotic Spindle Pole	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	DNA Binding Chromatin Binding RNA Binding Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding
	Biological Process	Mitotic Sister Chromatid Segregation DNA Repair Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Response To Radiation Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Response To DNA Damage Checkpoint Signaling Mitotic Spindle Assembly	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)	Cornelia de Lange syndrome (CdLS)
GWAS		Bipolar disorder ( 31043756) Mean corpuscular volume ( 32888494)	Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)
Interacting Genes		20 interacting genes: AMOT ATM BLM BRCA1 ESR1 FGF14 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3 SUMO2	18 interacting genes: APC CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1
Entrez ID		8243	9126
HPRD ID		02077	05829
Ensembl ID		ENSG00000072501	ENSG00000108055
Uniprot IDs		A0A384MR33 G8JLG1 Q14683 Q68EN4	Q9UQE7
PDB IDs		6WG3 6WG4 6WG6 6WGE	6WG3 6WG4 6WG6 6WGE
Enriched GO Terms of Interacting Partners?
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