ELL and EAF1

Data Source:
HPRD (in vivo)

		ELL	EAF1
Description		elongation factor for RNA polymerase II	ELL associated factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Transcriptionally Active Chromatin Histone Locus Body	Nucleoplasm Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Super Elongation Complex Intracellular Membrane-bounded Organelle Intercellular Bridge
	Molecular Function	Protein Binding Phosphatase Binding	Transcription Elongation Regulator Activity Protein Binding
	Biological Process	In Utero Embryonic Development Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Phosphatase Activity Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase III	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Transcription-Coupled Nucleotide Excision Repair (TC-NER) TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683 23535729) Coronary artery disease ( 29212778) HDL cholesterol levels ( 32203549) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Pulse pressure ( 30224653) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		13 interacting genes: CCAR2 EAF1 EAF2 EP300 HDAC3 HNRNPU MCM2 POLR2A SNF8 TFPT TP53 UBC ZHX1	53 interacting genes: AP2M1 APP ARID4B BEND7 BHLHB9 CCDC150 CCDC33 CEP70 CEP76 DNTTIP1 DPPA4 ELL ELL2 ELL3 FAM228A GADD45GIP1 GAS8 GCSAML GOLGA6L9 GRHL3 GTF2H1 GTF2H4 HOMER3 HSF2BP KEAP1 KIAA1328 MAB21L3 MIPOL1 NUMB PAX6 PICK1 PIH1D1 PSME3 RYBP SDCBP SEMG1 SH3RF1 SRP14 STAC3 TCEA2 TFCP2 TFPT TLE5 TNFAIP8 TNNI1 TRAF2 TRIM62 VAX1 YAF2 ZBTB14 ZNF143 ZNF202 ZNF620
Entrez ID		8178	85403
HPRD ID		02615	12209
Ensembl ID		ENSG00000105656	ENSG00000144597
Uniprot IDs		P55199 U3KQ90	Q96JC9
PDB IDs		2DOA
Enriched GO Terms of Interacting Partners?
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