UNC93B1 and CLPTM1

Data Source:
BioGRID (pull down)

		UNC93B1	CLPTM1
Description		unc-93 homolog B1, TLR signaling regulator	CLPTM1 regulator of GABA type A receptor forward trafficking
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Early Phagosome	Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endomembrane System Membrane
	Molecular Function	Protein Binding Toll-like Receptor Binding	Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Intracellular Protein Transport Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Defense Response To Virus	Multicellular Organism Development Cell Differentiation Regulation Of T Cell Differentiation In Thymus
Pathways		Trafficking and processing of endosomal TLR UNC93B1 deficiency - HSE
Drugs
Diseases
GWAS			Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein B levels ( 32203549) Basal cell carcinoma ( 31174203) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol levels ( 32203549) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		27 interacting genes: BEST2 CCDC107 CD79A CLDN7 CLPTM1 CREB3L1 EBP ERGIC3 FATE1 FFAR3 GPR101 GPR37L1 GPRC5D HHLA2 KLRC1 LDLRAD1 LEUTX LIME1 MBOAT7 MFF REEP1 SLC16A2 SLC35C2 SSMEM1 SYNDIG1 TM4SF18 TMEM237	8 interacting genes: CCR2 CCR4 F2RL1 FZD7 LINC00839 SLC22A1 SLC22A2 UNC93B1
Entrez ID		81622	1209
HPRD ID		12191	07544
Ensembl ID		ENSG00000110057	ENSG00000104853
Uniprot IDs		Q9H1C4	A0A0S2Z3H2 O96005
PDB IDs
Enriched GO Terms of Interacting Partners?
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