FAM83D and GADD45A

Data Source:
BioGRID (two hybrid)

		FAM83D	GADD45A
Description		family with sequence similarity 83 member D	growth arrest and DNA damage inducible alpha
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GO Annotations	Cellular Component	Cytoplasm Spindle Cytosol Microtubule Cytoskeleton Intercellular Bridge Mitotic Spindle Mitotic Spindle Pole	Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding	Protein Binding Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein N-terminus Binding Promoter-specific Chromatin Binding
	Biological Process	Epithelial To Mesenchymal Transition Signal Transduction Cell Population Proliferation Cell Migration Regulation Of TOR Signaling Regulation Of Protein Catabolic Process Cell Division Metaphase Plate Congression Regulation Of ERK1 And ERK2 Cascade Protein Localization To Mitotic Spindle Positive Regulation Of Cell Cycle G1/S Phase Transition	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPKKK Activity DNA Repair Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Centrosome Cycle Negative Regulation Of Angiogenesis Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Mitotic Cell Cycle Arrest Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS		Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis ( 28714907) Huntington's disease progression ( 28642124)	Bone mineral density (hip) ( 30172743) Mean corpuscular volume ( 29403010) Offspring birth weight ( 31043758) Optic disc area ( 28073927) Optic disc size ( 31809533) Platelet distribution width ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		5 interacting genes: CSNK1E DYNC1I1 GADD45A GSK3B PRMT1	69 interacting genes: ADAP1 ASCC2 AURKA BAG6 CBY2 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B CNOT9 DCTN2 DNAJC13 EEF1A1 EEF1G ERG28 FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 H1-1 H2AC16 H2BC21 H3-4 H4-16 IGHM IGSF21 JMJD1C KHSRP LMO4 LNX2 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PARVG PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS1 RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135
Entrez ID		81610	1647
HPRD ID		12744	00528
Ensembl ID		ENSG00000101447	ENSG00000116717
Uniprot IDs		Q9H4H8	A5JUZ3 P24522
PDB IDs		5E0L 5E0M	2KG4
Enriched GO Terms of Interacting Partners?
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