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GADD45A and KHSRP
Data Source:
BioGRID
(two hybrid)
GADD45A
KHSRP
Description
growth arrest and DNA damage inducible alpha
KH-type splicing regulatory protein
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Molecular Function
Protein Binding
Kinase Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein N-terminus Binding
Promoter-specific Chromatin Binding
DNA Binding
RNA Binding
MRNA Binding
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPKKK Activity
DNA Repair
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Centrosome Cycle
Negative Regulation Of Angiogenesis
Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Signal Transduction In Response To DNA Damage
Positive Regulation Of Apoptotic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of JNK Cascade
Regulation Of Cell Cycle
Cellular Response To Mechanical Stimulus
Cellular Response To Ionizing Radiation
Mitotic Cell Cycle Arrest
Negative Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Reactive Oxygen Species Metabolic Process
RNA Splicing, Via Transesterification Reactions
Regulation Of Transcription, DNA-templated
MRNA Processing
RNA Splicing
Regulation Of Gene Expression
MiRNA Metabolic Process
Negative Regulation Of Low-density Lipoprotein Particle Clearance
Regulation Of MRNA Stability
Negative Regulation Of Nitric Oxide Biosynthetic Process
MRNA Transport
Positive Regulation Of MRNA Catabolic Process
3'-UTR-mediated MRNA Destabilization
Cellular Response To Cytokine Stimulus
Pathways
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
FOXO-mediated transcription of cell cycle genes
ATF4 activates genes in response to endoplasmic reticulum stress
KSRP (KHSRP) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Drugs
Resveratrol
Artenimol
Diseases
GWAS
Bone mineral density (hip) (
30172743
)
Mean corpuscular volume (
29403010
)
Offspring birth weight (
31043758
)
Optic disc area (
28073927
)
Optic disc size (
31809533
)
Platelet distribution width (
32888494
)
Red blood cell count (
32888494
)
Interacting Genes
69 interacting genes:
ADAP1
ASCC2
AURKA
BAG6
CBY2
CCNB1
CDK1
CDK11A
CDKN1A
CENPB
CHD3
CLEC3B
CNOT9
DCTN2
DNAJC13
EEF1A1
EEF1G
ERG28
FAM83D
FAS
FBN3
FTL
GADD45GIP1
GAPDH
GBP2
GNB2
H1-1
H2AC16
H2BC21
H3-4
H4-16
IGHM
IGSF21
JMJD1C
KHSRP
LMO4
LNX2
MAP3K4
MAPK14
MASP1
MDM2
MICAL1
MIDN
MPP1
NPM1
NRBP1
NUCB2
PARVG
PCNA
PFKFB4
PPARA
PSMC3
PTN
PTPRK
QARS1
RAI1
RBPJ
RPS2
RXRA
SH3GLB1
SPTBN4
SYNE4
TLE1
TP53
UBE2D1
UBR1
VIM
ZHX1
ZNF135
14 interacting genes:
A1CF
APBB1
BACE1
EXOSC2
EXOSC3
GADD45A
GSK3B
HNRNPA1
HNRNPH1
KLHL12
PARN
PTBP2
STK3
UBE2I
Entrez ID
1647
8570
HPRD ID
00528
10350
Ensembl ID
ENSG00000116717
ENSG00000088247
Uniprot IDs
A5JUZ3
P24522
Q92945
PDB IDs
2KG4
2HH2
2HH3
2JVZ
2OPU
2OPV
4B8T
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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