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GADD45A and DCTN2
Data Source:
BioGRID
(two hybrid, two hybrid)
HPRD
(two hybrid)
GADD45A
DCTN2
Description
growth arrest and DNA damage inducible alpha
dynactin subunit 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
Kinetochore
Cytoplasm
Centrosome
Cytosol
Dynactin Complex
Microtubule
Membrane
Dynein Complex
Growth Cone
Vesicle
Extracellular Exosome
Molecular Function
Protein Binding
Kinase Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein N-terminus Binding
Promoter-specific Chromatin Binding
Motor Activity
Protein Binding
Protein Kinase Binding
Spectrin Binding
Identical Protein Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPKKK Activity
DNA Repair
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Centrosome Cycle
Negative Regulation Of Angiogenesis
Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Signal Transduction In Response To DNA Damage
Positive Regulation Of Apoptotic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of JNK Cascade
Regulation Of Cell Cycle
Cellular Response To Mechanical Stimulus
Cellular Response To Ionizing Radiation
Mitotic Cell Cycle Arrest
Negative Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Reactive Oxygen Species Metabolic Process
G2/M Transition Of Mitotic Cell Cycle
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Mitotic Spindle Organization
Mitotic Metaphase Plate Congression
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Melanosome Transport
Protein Localization To Centrosome
Ciliary Basal Body-plasma Membrane Docking
Pathways
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
FOXO-mediated transcription of cell cycle genes
MHC class II antigen presentation
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
AURKA Activation by TPX2
Drugs
Diseases
GWAS
Bone mineral density (hip) (
30172743
)
Mean corpuscular volume (
29403010
)
Offspring birth weight (
31043758
)
Optic disc area (
28073927
)
Optic disc size (
31809533
)
Platelet distribution width (
32888494
)
Red blood cell count (
32888494
)
Brain morphology (MOSTest) (
32665545
)
Interacting Genes
69 interacting genes:
ADAP1
ASCC2
AURKA
BAG6
CBY2
CCNB1
CDK1
CDK11A
CDKN1A
CENPB
CHD3
CLEC3B
CNOT9
DCTN2
DNAJC13
EEF1A1
EEF1G
ERG28
FAM83D
FAS
FBN3
FTL
GADD45GIP1
GAPDH
GBP2
GNB2
H1-1
H2AC16
H2BC21
H3-4
H4-16
IGHM
IGSF21
JMJD1C
KHSRP
LMO4
LNX2
MAP3K4
MAPK14
MASP1
MDM2
MICAL1
MIDN
MPP1
NPM1
NRBP1
NUCB2
PARVG
PCNA
PFKFB4
PPARA
PSMC3
PTN
PTPRK
QARS1
RAI1
RBPJ
RPS2
RXRA
SH3GLB1
SPTBN4
SYNE4
TLE1
TP53
UBE2D1
UBR1
VIM
ZHX1
ZNF135
35 interacting genes:
ABI2
BICD1
BICD2
BLOC1S1
BLOC1S2
BLOC1S6
BORCS6
CALM1
CCDC172
CENPH
CEP44
COG3
DISC1
EGFR
GADD45A
GADD45G
GNAO1
GOLM1
GRB2
GSK3B
HAUS1
HGS
KIFC3
KPNA2
MAPK6
MAPRE3
MARCKSL1
PAFAH1B1
RABGEF1
RINT1
RPGR
SMARCD1
TXLNB
USHBP1
ZW10
Entrez ID
1647
10540
HPRD ID
00528
09568
Ensembl ID
ENSG00000116717
ENSG00000175203
Uniprot IDs
A5JUZ3
P24522
A0A384MDU9
A8K8J9
B3KTX4
Q13561
V9HW58
PDB IDs
2KG4
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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