ACTN4 and MICALL2

Data Source:
BioGRID (two hybrid)

		ACTN4	MICALL2
Description		actinin alpha 4	MICAL like 2
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Actin Cytoskeleton Nuclear Body Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Ribonucleoprotein Complex	Stress Fiber Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Actin Filament Bundle Neuron Projection Recycling Endosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Ion Channel Binding Protein N-terminus Binding Actin Filament Binding	Protein Binding Filamin Binding Small GTPase Binding Actinin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Response To Hypoxia Platelet Degranulation Protein Transport Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cellular Component Movement Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Nucleic Acid-templated Transcription	Actin Filament Polymerization Neuron Projection Development Actin Cytoskeleton Reorganization Endocytic Recycling Substrate Adhesion-dependent Cell Spreading Bicellular Tight Junction Assembly Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Platelet degranulation Nephrin family interactions
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Brain morphology (MOSTest) ( 32665545) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)	Blood urea nitrogen levels ( 29403010) Creatinine levels ( 29403010) Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder ( 28416812) Glomerular filtration rate ( 29403010) Hematocrit ( 29403010) Hemoglobin ( 29403010) Red blood cell count ( 29403010) Resistance to antihypertensive treatment in hypertension ( 31545351) Serum uric acid levels ( 30993211 29403010) Zinc levels ( 26025379)
Interacting Genes		55 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 DDIAS ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR	6 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 CDR2 DCDC2
Entrez ID		81	79778
HPRD ID		05222	11364
Ensembl ID		ENSG00000130402	ENSG00000164877
Uniprot IDs		A0A0S2Z3G9 O43707	Q6UWK3 Q8IY33
PDB IDs		1WLX 1YDI 2R0O 6O31 6OA6
Enriched GO Terms of Interacting Partners?
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