ACTN4 and INO80

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ACTN4	INO80
Description		actinin alpha 4	INO80 complex ATPase subunit
Image
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Actin Cytoskeleton Nuclear Body Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Spindle Cytosol Microtubule Nuclear Body Ino80 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Ion Channel Binding Protein N-terminus Binding Actin Filament Binding	DNA Binding Actin Binding Protein Binding ATP Binding DNA-dependent ATPase Activity ATPase Activity Histone Binding Alpha-tubulin Binding 3'-5' DNA Helicase Activity
	Biological Process	Response To Hypoxia Platelet Degranulation Protein Transport Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cellular Component Movement Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Nucleic Acid-templated Transcription	Mitotic Sister Chromatid Segregation Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Chromatin Remodeling Transcription, DNA-templated Positive Regulation Of Nuclear Cell Cycle DNA Replication Protein Deubiquitination Positive Regulation Of Cell Growth DNA Duplex Unwinding Cellular Response To UV Nucleosome Mobilization ATP-dependent Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription By RNA Polymerase II Spindle Assembly Cell Division UV-damage Excision Repair Cellular Response To Ionizing Radiation Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Platelet degranulation Nephrin family interactions	UCH proteinases DNA Damage Recognition in GG-NER
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Brain morphology (MOSTest) ( 32665545) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Macular thickness ( 30535121) Malaria ( 31844061) Menopause (age at onset) ( 26414677) Offspring birth weight ( 31043758) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908)
Interacting Genes		55 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 DDIAS ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR	3 interacting genes: ACTN4 PLEKHF2 YY1
Entrez ID		81	54617
HPRD ID		05222	10024
Ensembl ID		ENSG00000130402	ENSG00000128908
Uniprot IDs		A0A0S2Z3G9 O43707	A0A024R9R7 Q9ULG1
PDB IDs		1WLX 1YDI 2R0O 6O31 6OA6	6HTS
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?