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BHLHB9 and PPP2R5E
Data Source:
HPRD
(two hybrid)
BHLHB9
PPP2R5E
Description
basic helix-loop-helix family member b9
protein phosphatase 2 regulatory subunit B'epsilon
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Extracellular Exosome
Protein Phosphatase Type 2A Complex
Nucleus
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Protein Homodimerization Activity
Protein Binding
Protein Phosphatase Regulator Activity
Protein Phosphatase Activator Activity
Biological Process
Learning Or Memory
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neurogenesis
Positive Regulation Of Synapse Assembly
Positive Regulation Of Dendritic Spine Morphogenesis
Protein Dephosphorylation
Signal Transduction
Regulation Of Protein Autophosphorylation
Regulation Of Phosphoprotein Phosphatase Activity
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Low density lipoprotein cholesterol levels (
32154731
)
Response to antineoplastic agents (
21659360
)
Systolic blood pressure (
28135244
)
Triglyceride levels (
32154731
)
Interacting Genes
59 interacting genes:
ANKRD11
APP
AQP1
BEX2
C2CD6
CCDC120
CDC23
CDC37
CDCA7L
CT55
DDX6
EAF1
EIF3B
ENKD1
FAM124B
FAM161A
FAM214B
FAM90A1
GAS8
GEM
GPANK1
HOXA1
INO80B
IPO5
IQUB
KLHL38
L3MBTL2
LEO1
LMO1
LONRF1
MFAP1
MISP
MPP1
MYO15B
NRIP1
OTX1
PALS1
PHF1
PNMA5
POLR1C
PPP2R5E
PRKAB2
PRPF31
RCOR3
SCNM1
SH3KBP1
SMARCD1
SPANXN2
TASOR2
TCEA2
TEPSIN
THOC1
TLK1
TOP3B
TSGA10IP
TXN2
USP2
USP20
ZNF417
20 interacting genes:
APP
BHLHB9
BHLHE41
CHEK2
CLOCK
CRY1
CRY2
CSNK1E
CSNK2B
DELEC1
DOCK9
ENO1
FBXW11
PPP1CA
PPP2CA
PPP2R1B
RACGAP1
RORC
SGO1
SMAD9
Entrez ID
80823
5529
HPRD ID
10028
09040
Ensembl ID
ENSG00000198908
ENSG00000154001
Uniprot IDs
Q6PI77
Q16537
PDB IDs
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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