PPP2R5E and BHLHE41

Data Source:
BioGRID (two hybrid)

		PPP2R5E	BHLHE41
Description		protein phosphatase 2 regulatory subunit B'epsilon	basic helix-loop-helix family member e41
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol	Chromatin Nucleus
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Dephosphorylation Signal Transduction Regulation Of Protein Autophosphorylation Regulation Of Phosphoprotein Phosphatase Activity	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Negative Regulation Of Myotube Differentiation Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	BMAL1:CLOCK,NPAS2 activates circadian gene expression Circadian Clock
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Response to antineoplastic agents ( 21659360) Systolic blood pressure ( 28135244) Triglyceride levels ( 32154731)	Response to bupropion and depression ( 27622933) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		20 interacting genes: APP BHLHB9 BHLHE41 CHEK2 CLOCK CRY1 CRY2 CSNK1E CSNK2B DELEC1 DOCK9 ENO1 FBXW11 PPP1CA PPP2CA PPP2R1B RACGAP1 RORC SGO1 SMAD9	22 interacting genes: BHLHE40 CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DELEC1 FBXW11 GSK3B MYOD1 NONO PER2 PPP2CB PPP2R1B PPP2R5E RASD1 RORA RORC SIRT1 WDR5
Entrez ID		5529	79365
HPRD ID		09040	16204
Ensembl ID		ENSG00000154001	ENSG00000123095
Uniprot IDs		Q16537	A0A024RAV8 Q8TAT1 Q9C0J9
PDB IDs
Enriched GO Terms of Interacting Partners?
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