EFHC2 and INPP5J

Data Source:
BioGRID (two hybrid)

		EFHC2	INPP5J
Description		EF-hand domain containing 2	inositol polyphosphate-5-phosphatase J
Image			No pdb structure
GO Annotations	Cellular Component	Microtubule Axoneme Ciliary Basal Body Mitotic Spindle	Ruffle Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Membrane Growth Cone Dendritic Shaft
	Molecular Function	Calcium Ion Binding Protein Binding Alpha-tubulin Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Mitotic Cytokinesis Mitotic Spindle Organization Regulation Of Neuron Projection Development Cilium-dependent Cell Motility Cellular Response To Leukemia Inhibitory Factor	Phosphatidylinositol Biosynthetic Process Negative Regulation Of Neuron Projection Development Negative Regulation Of Microtubule Polymerization Negative Regulation Of Peptidyl-serine Phosphorylation Inositol Phosphate Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation
Pathways			Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases
GWAS		Mean arterial pressure ( 29403010)	Fish- and plant-related diet ( 32066663) Gut microbiota (beta diversity) ( 27723756) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		100 interacting genes: AASDHPPT ARHGEF5 ARMC7 CABP2 CACNB4 CARD9 CCDC102B CCDC120 CCDC13 CCDC57 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CPNE2 CPNE7 CYFIP1 DCLK1 DDX6 DGCR6 DRC7 EDC3 EFHC1 EGLN3 EMD ENKD1 ESRRG EXOC8 EXOSC5 FAM107A FAM124B FAM214B FAM221B FBXL19 GEM GLYCTK GOLGA1 GPKOW GRB2 GYS1 HDAC4 HGS HNRNPLL INPP5J JAKMIP2 KANK2 KCTD7 KIF9 L3MBTL2 LMNB2 LMO2 LNX1 LONRF1 MAGOHB MAPK9 MID2 MISP MYLIP MYO5B NCDN NCK2 NDOR1 NEK6 NFKBID NME7 NR3C1 PBLD PHF1 PIBF1 PICK1 PLOD3 POLR1C PRPF18 PTK6 QARS1 RAD51D RCOR3 RECK RHOBTB3 RUNX1T1 SNRNP25 SOGA1 SPATA18 SPG21 STK16 TBC1D1 TBC1D22B TEKT4 TRIM42 TRIM50 TSSK3 TUBGCP4 TXK U2AF1 U2AF1L5 USP2 ZBTB16 ZFHX3 ZZZ3	18 interacting genes: CDC23 CEP70 DNAJA3 EFHC2 EPS8 FXR2 GOLGA2 HSF2BP MEOX1 MEOX2 PELI1 PICK1 PRKAR1B PSME3 RINT1 TLE5 TRIM27 TRIM54
Entrez ID		80258	27124
HPRD ID		06540	07573
Ensembl ID		ENSG00000183690	ENSG00000185133
Uniprot IDs		Q5JST6	A0A087WVS7 B4DF95 Q15735
PDB IDs		2Z13 2Z14
Enriched GO Terms of Interacting Partners?
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