INPP5J and EPS8

Data Source:
BioGRID (two hybrid)

		INPP5J	EPS8
Description		inositol polyphosphate-5-phosphatase J	epidermal growth factor receptor pathway substrate 8
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Membrane Growth Cone Dendritic Shaft	Plasma Membrane Cell Cortex Growth Cone Vesicle Stereocilium Ruffle Membrane Synapse Extracellular Exosome
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity	Actin Binding Protein Binding Small GTPase Binding Signaling Adaptor Activity
	Biological Process	Phosphatidylinositol Biosynthetic Process Negative Regulation Of Neuron Projection Development Negative Regulation Of Microtubule Polymerization Negative Regulation Of Peptidyl-serine Phosphorylation Inositol Phosphate Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation	Rho Protein Signal Transduction Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Regulation Of Catalytic Activity Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Positive Regulation Of Ruffle Assembly
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases
GWAS		Fish- and plant-related diet ( 32066663) Gut microbiota (beta diversity) ( 27723756) Oily fish consumption ( 32066663) Pork consumption ( 32066663)	Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)
Interacting Genes		18 interacting genes: CDC23 CEP70 DNAJA3 EFHC2 EPS8 FXR2 GOLGA2 HSF2BP MEOX1 MEOX2 PELI1 PICK1 PRKAR1B PSME3 RINT1 TLE5 TRIM27 TRIM54	61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3
Entrez ID		27124	2059
HPRD ID		07573	02563
Ensembl ID		ENSG00000185133	ENSG00000151491
Uniprot IDs		A0A087WVS7 B4DF95 Q15735	B4E3T6 Q12929
PDB IDs			2E8M
Enriched GO Terms of Interacting Partners?
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