NUP214 and LSS

Data Source:
BioGRID (proximity labelling technology)

		NUP214	LSS
Description		nucleoporin 214	lanosterol synthase
Image
GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytosol Host Cell Cytoplasmic Side Of Nuclear Pore	Endoplasmic Reticulum Membrane Lipid Droplet Membrane
	Molecular Function	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	Lanosterol Synthase Activity Protein Binding Beta-amyrin Synthase Activity
	Biological Process	Mitotic Cell Cycle Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of MRNA Stability Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability Regulation Of Cholesterol Biosynthetic Process
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs			R048-8071 Lanosterol
Diseases
GWAS		Aspartate aminotransferase levels ( 31219225)	White blood cell count ( 27863252)
Interacting Genes		20 interacting genes: APC CLEC4G DDX19B IPO5 NFX1 NUP107 NUP42 NUP62 NUP88 NXF1 NXF2 SMAD2 SMAD3 SMAD4 SUMO2 TNPO1 XPO1 XPO5 XPOT ZFP36	9 interacting genes: AQP6 CIB1 GPR35 NR4A1 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A
Entrez ID		8021	4047
HPRD ID		00258	02945
Ensembl ID		ENSG00000126883	ENSG00000160285
Uniprot IDs		B7ZAV2 P35658	B2R694 P48449
PDB IDs		2OIT 3FHC 3FMO 3FMP 5DIS	1W6J 1W6K
Enriched GO Terms of Interacting Partners?
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