TMEM254 and SEC11C

Data Source:
BioGRID (two hybrid)

		TMEM254	SEC11C
Description		transmembrane protein 254	SEC11 homolog C, signal peptidase complex subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity
	Biological Process		Signal Peptide Processing
Pathways			SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS			Alzheimer's disease (age of onset) ( 22005931) Chronotype ( 30696823) Morning person ( 30696823)
Interacting Genes		41 interacting genes: AQP6 ARL13B ATP6V0E1 BCL2L13 BIK CD74 CD79A CERS4 CPLX4 EBP ELOVL4 FAM209A FKBP8 FNDC9 GPR152 GPX8 IFNGR2 IL3RA LEUTX LHFPL5 MFF MMGT1 MTIF3 PAGE1 PLP1 REEP4 RETREG3 SAR1A SEC11C SLC16A2 STOM STX1A SYT1 TMED8 TMEM14B TMEM237 TMEM31 TMEM45B TMEM51 TMEM79 TMX2	23 interacting genes: BTN2A2 C2 CADM3 GLP1R HMOX1 MFF PLPP6 PRSS23 RTP2 SCD SELENOM SERP1 STX12 TMEM128 TMEM243 TMEM254 TMEM42 TREX1 TSNARE1 UBE2J1 VAMP1 VAMP4 VAPA
Entrez ID		80195	90701
HPRD ID		08501	15310
Ensembl ID		ENSG00000133678	ENSG00000166562
Uniprot IDs		A0A087WZM8 B4DU43 Q8TBM7	K7EJQ7 Q9BY50
PDB IDs
Enriched GO Terms of Interacting Partners?
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