THOC7 and NIF3L1

Data Source:
HPRD (two hybrid)

		THOC7	NIF3L1
Description		THO complex 7	NGG1 interacting factor 3 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Nucleus Cytoplasm Mitochondrion
	Molecular Function	RNA Binding Protein Binding	Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA 3'-end Processing Viral MRNA Export From Host Cell Nucleus	Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Neutrophil count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)	Triptolide cytotoxicity ( 26121980)
Interacting Genes		11 interacting genes: CCDC146 CHD3 CKAP4 GOT2 MED22 MED8 MNS1 NDC80 NIF3L1 SMARCD1 THOC5	93 interacting genes: ALKBH4 AP5B1 APIP ARPIN BDKRB2 BEND7 C14orf119 CASP7 CCDC102B CCDC85B CDKN2B CDKN2C CDKN2D COIL COPS2 CUTC CYRIB DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DTX2 DUSP23 DUSP29 DYNLT3 EIF4A3 EIF5A2 ENOX1 EPHB6 FLAD1 FXR2 GNMT GRB2 IP6K3 KCNIP1 KCTD17 KCTD7 KCTD9 KRT15 KXD1 LAMTOR3 LMO2 LMO3 MAGEA11 MAPRE2 MLXIPL NATD1 NEK6 NGB NME1 NME7 NOL3 NUDT14 NUDT21 ORC5 PAFAH1B3 PAICS PCBD1 PNMA1 POLR1C PPIH PRTFDC1 PTPA RABAC1 RAD54B RPIA S100A1 SAT1 SEPTIN1 SNF8 SPG21 SSX2IP STAT3 STK16 SULT1A2 SULT1A3 SULT2A1 SYT17 TCL1A THOC7 TIFA TRAF2 TRIM21 TRIM27 TRIP13 TSC22D4 TXN VIM YES1 YWHAQ ZBED1
Entrez ID		80145	60491
HPRD ID		17632	10424
Ensembl ID		ENSG00000163634	ENSG00000196290
Uniprot IDs		A0A024R332 A0A5S6STF9 Q6I9Y2	A0A024R3V5 A0A024R3V7 Q9GZT8
PDB IDs
Enriched GO Terms of Interacting Partners?
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