CCR2 and GOT1

Data Source:
BioGRID (two hybrid)

		CCR2	GOT1
Description		C-C motif chemokine receptor 2	glutamic-oxaloacetic transaminase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Dendrite Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Axon Terminus Extracellular Exosome
	Molecular Function	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding CCR2 Chemokine Receptor Binding Identical Protein Binding	L-aspartate:2-oxoglutarate Aminotransferase Activity Phosphatidylserine Decarboxylase Activity Pyridoxal Phosphate Binding Carboxylic Acid Binding L-cysteine:2-oxoglutarate Aminotransferase Activity
	Biological Process	Blood Vessel Remodeling Dendritic Cell Chemotaxis Regulation Of T Cell Cytokine Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cellular Defense Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor Signaling Pathway Via JAK-STAT Response To Wounding Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of T Cell Chemotaxis Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Calcium-mediated Signaling Cellular Homeostasis Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Monocyte Extravasation T-helper 17 Cell Chemotaxis Negative Regulation Of Eosinophil Degranulation Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Inflammatory Response To Wounding Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of NMDA Glutamate Receptor Activity Macrophage Migration Positive Regulation Of Thymocyte Migration Positive Regulation Of Monocyte Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Positive Regulation Of Astrocyte Chemotaxis Positive Regulation Of Hematopoietic Stem Cell Migration	Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Glycerol Biosynthetic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Notch Signaling Pathway Cellular Amino Acid Biosynthetic Process Response To Carbohydrate Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Response To Immobilization Stress Response To Cadmium Ion Response To Glucocorticoid Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Fatty Acid Homeostasis Transdifferentiation Cellular Response To Mechanical Stimulus Response To Transition Metal Nanoparticle
Pathways		Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Methionine salvage pathway Gluconeogenesis Aspartate and asparagine metabolism
Drugs		INCB3284 CCX915 Plozalizumab	Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine Adapalene Maleic Acid Copper
Diseases
GWAS		Blood protein levels ( 28240269 23696881) Celiac disease ( 22057235 20190752 25920553 24999842) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 32868391) Ulcerative colitis ( 26192919 28067908)	Aspartate aminotransferase levels ( 30718733 21900944) Crohn's disease ( 22412388) Hypothyroidism ( 27182965) Liver enzyme levels (aspartate transaminase) ( 24124411) Mean corpuscular volume ( 29403010) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		40 interacting genes: APP ARL6IP5 ATP2B1 B3GAT3 BLOC1S6 CACYBP CD59 CD81 CDIP1 CLPTM1 DMWD EMC10 ERGIC3 GOT1 GPR161 HERPUD1 HMOX2 JPH3 NDFIP1 NOTCH2 NTNG2 PCMT1 PLLP PTPN9 RGR RHOG RTN3 S1PR5 SCG5 SLC2A1 SLC41A3 SRSF5 SUMO1 SVOP TECPR2 TMEM161A TMEM199 TMEM63A TSPAN7 WLS	6 interacting genes: ABI3BP AGTR1 CCR2 EGFR PC TMEM120A
Entrez ID		729230	2805
HPRD ID		19667	00687
Ensembl ID		ENSG00000121807	ENSG00000120053
Uniprot IDs		A0A024R2Q0 P41597	A0A140VK69 P17174
PDB IDs		1KAD 1KP1 2MLO 2MLQ 5T1A	3II0 3WZF 6DNA 6DNB 6DND
Enriched GO Terms of Interacting Partners?
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